Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Biodegradation of dairy effluent by using microbial isolates obtained from activated sludge
Water resources are of significant importance to human beings. The present investigation was carried out for biodegradation of dairy effluent by using selected aerobic microbial isolates and a model having layers of sawdust and activated charcoal as ...
H.J. Porwal, A.V. Mane, S.G. Velhal
doaj +1 more source
Variations in the Yamuna River Water Quality During the COVID-19 Lockdowns
The COVID-19 pandemic that emerged in Wuhan city of China in December 2019 has adversely impacted the health and the economy, society, and other significant spheres of the human environment.
Bhupendra Pratap Singh +8 more
doaj +1 more source
Jupiter Oxygen Corporation/Albany Research Center Crada Progress Report, September
The Albany Research Center (ARC) has developed a new Integrated Pollutant Removal (IPR) process for fossil-fueled boilers. Pursuant to a cooperative research and development agreement (CRADA) with Jupiter Oxygen Corporation, ARC currently is studying the
Turner, Paul C. +1 more
core +1 more source
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Evaluation of Wastewater Characteristics in the Urban Area of Sulaimanyah Governorate in Kurdistan-Iraq [PDF]
The population of Iraqi Kurdistan region is increasing rapidly. This has increased pressure on water supply and waste water management in the region. The Sulaimanyah city and other cities of Iraqi Kurdistan region are facing serious challenges in this ...
Abdulfattah Ahmad Amin
doaj +1 more source
In situ characterization of sediment oxygen demand across the spectrum of non-resuspension to full resuspension with varying bed shear stress [PDF]
Sediment oxygen demand (SOD) can be a significant oxygen sink in various types of water bodies, particularly slow-moving waters with substantial organic sediment accumulation.
Waterman, David M.
core
Liver organoids: modelling complexity in homeostasis and disease
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Abstract Business activities of laying chicken farm in Sidrap regency have been carried out for decades. This business is a hereditary business carried out by the local community. The number of chicken populations is also increasing as the demand for animal protein increases. This activity can lead to a decrease in water quality, thereby
A B Abdullahi +3 more
openaire +1 more source

