Results 81 to 90 of about 5,249,949 (293)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

WATER POLLUTION LEVELS IN THE SUWUNG ESTUARY, BALI, BASED ON BIOLOGICAL OXYGEN DEMAND

Biotropia: The Southeast Asian Journal of Tropical Biology, 2018
Biological Oxygen Demand (BOD) is generally used for determining water pollution levels in bodies of water. Estuary is a semi-enclosed body of water that can be polluted via land areas or rivers.
Ni Luh Gede Rai Ayu Saraswati, I Wayan Arthana, I Gede Surya Risuana, I Gede Hendrawan   +3 more
doaj   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

A Terrestrial Single Chamber Microbial Fuel Cell-based Biosensor for Biochemical Oxygen Demand of Synthetic Rice Washed Wastewater

Sensors, 2016
Microbial fuel cells represent an innovative technology which allow simultaneous waste treatment, electricity production, and environmental monitoring.
Washington Logroño, Alex Guambo, Mario Pérez, Abudukeremu Kadier, Celso Recalde   +4 more
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Characterization of Hospital Laboratories Effluents

Journal of Environmental Science
Wastewater from hospital laboratories carries a complex mixture of contaminants, including organic matter, nutrients, traces of pharmaceuticals, antibiotic-resistant microorganisms, and potentially harmful viruses.
MANAR MOHAMED OMAR
doaj   +1 more source

Wisconsin Oxygen/Hydrogen Company, Kenosha, Wisconsin 1920-1925

, 1920
It wasn’t long before the Brant Brothers expanded their entrepreneurial efforts to Kenosha, Wisconsin, where they built a second electrolytic oxygen/hydrogen plant, known as Wisconsin Oxygen/Hydrogen Company.

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Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Indiana Oxygen Building, Indianapolis

, 1930
By 1930, business was booming and Indiana Oxygen moved to a larger building at 435 S. Delaware St. At the same time, technology had also advanced, and Indiana Oxygen turned to a new process known as Atmospheric Air Separation.

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