Results 91 to 100 of about 5,013,780 (327)

Automated construction of genetic networks from mutant data [PDF]

, 2003
Geneticists use mutations to investigate biological phenomena. Mutations cause changes of organism’s phenotype and may reveal which genes participate in a certain biological process and how.
Juvan, Peter, Shaulsky, Gad, Zupan, Blaz
core  

Canalizing Kauffman networks: non-ergodicity and its effect on their critical behavior

, 2005
Boolean Networks have been used to study numerous phenomena, including gene regulation, neural networks, social interactions, and biological evolution. Here, we propose a general method for determining the critical behavior of Boolean systems built from ...
André Auto Moreira, B. Derrida, J. Kahn, Luís A. Nunes Amaral, M. Aldana, S. Wassermann, S. A. Kauffman   +6 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Migration dynamics of an important rice pest: The brown planthopper (Nilaparvata lugens) across Asia—Insights from population genomics

Evolutionary Applications, 2020
Introduction Brown planthoppers (Nilaparvata lugens) are the most serious insect pests of rice, one of the world's most important staple crops. They reproduce year‐round in the tropical parts of their distribution, but cannot overwinter in the temperate ...
James P. Hereward, Xuhong Cai, Ambrocio Melvin A. Matias, Gimme H. Walter, Chenxi Xu, Yongmo Wang   +5 more
doaj   +1 more source

Phase transitions in biological membranes

, 2018
Native membranes of biological cells display melting transitions of their lipids at a temperature of 10-20 degrees below body temperature. Such transitions can be observed in various bacterial cells, in nerves, in cancer cells, but also in lung ...
A Blicher, A Blicher, A Gonzalez-Perez, A Gonzalez-Perez, A Hac, A Punnia-Moorthy, AG Lee, AL Hodgkin, AL Hodgkin, B Lautrup, D Johnston, D Papahadjopoulos, DB Mountcastle, DP Kharakoz, E London, EF DeLong, FH Johnson, FH Johnson, GH Kim, GS Manning, H Ebel, H Kamaya, H Kamaya, H Kamaya, H Träuble, HJ Galla, HM Seeger, HM Seeger, I Tasaki, J Gallaher, J Marmur, JE Rothman, JE Rothman, JLCM Vossenberg van de, JM Ritchie, JR Hazel, JR Hazel, JR Trudell, K Græsbøll, K Iwasa, K Iwasa, K Simons, KA Zecchi, KR Laub, L Onsager, LD Mosgaard, LD Mosgaard, LO Ingram, M Gudmand, M Moldovan, MC Sabra, MJ Halsey, MJ Pringle, OG Mouritsen, P Grabitz, PF Almeida, PL Privalov, R Böckmann, R Ravindra, R Winter, RS Cantor, RS Cantor, RW Glaser, S Johnson, SV Avery, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Heimburg, T Horishita, Tian Wang, UR Pedersen, Y Kaminoh, Y Zuo   +76 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Effects of Saline Solutions on Paper-Based Cultural Heritage: Non-Invasive Techniques for Studying Flooded Ancient Books

Heritage
Archival materials are increasingly vulnerable to damage from chemical, physical, biological, and environmental factors, including climate change-related extreme weather events such as torrential rains and flash floods.
Tullia Carla David, Francesca Assunta Pisu, Stefania Porcu, Carlo Maria Carbonaro, Jarmila Kodric, Daniele Chiriu   +5 more
doaj   +1 more source

Memory circuit elements: from systems to applications

, 2010
In this paper, we briefly review the concept of memory circuit elements, namely memristors, memcapacitors and meminductors, and then discuss some applications by focusing mainly on the first class.
Di Ventra, M., Martinez-Rincon, J., Pershin, Y. V.   +2 more
core   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Nonlinear phenomena of Fröhlich phonons in biological media

Moldavian Journal of the Physical Sciences, 2013
Nonlinear cooperative stationary phenomena are studied for the interaction of Bose-condensed phonons with millimeter electromagnetic radiation in the biological media.
Rotaru, Anatol, Ciobanu, Nellu, Tronciu, Vasile   +2 more
doaj