Results 161 to 170 of about 2,302,526 (216)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Unearthing forensic genetics: preliminary results on the ability to generate DNA profiles from buried human biological samples. [PDF]

Int J Legal Med
Gracia-de-Lucas S, López-Matayoshi C, Lozano-García M, Gomes C.   +3 more
europepmc   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Artifact-free preparation of biological samples for SEM by optimized water freeze-drying. [PDF]

Sci Rep
Ishida H, Fukuda N, Shimada M, Yamamoto K, Gaponova L, Higuchi R, Kolosiuk A, Hoshina R, Arikawa M, Fukuda Y, Islam MDS, Harumoto T, Wan Y, Itoh T, Inai Y, Takeishi A, Aonuma H, Kikuchi T, Nishigori S, Maruyama T, Ikeda K, Iriko H, Suzaki T.   +22 more
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Radiation-dose effects in correlative X-ray/cryo-electron microscopy of frozen-hydrated biological samples. [PDF]

Acta Crystallogr D Struct Biol
Blum TB, Olieric V, Diaz A, Ishikawa T, Korkhov VM.   +4 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Asthma-Associated COPD Etiotype: Clinical Features and Inflammatory Patterns in Biological Samples. [PDF]

J Pers Med
de Farias CF, Baddini-Martinez J, Fernandes ALG, Amorim MM, Dracoulakis M, Santos MA, Caetano LB, Filho FSL.   +7 more
europepmc   +1 more source