Results 211 to 220 of about 702,953 (323)

Evaluation and modification of tumor cell isolation techniques from malignant effusions for rapid drug sensitivity testing

Molecular Oncology, EarlyView.
Non‐small cell lung cancer targeted treatment is limited to a few known genetic alterations, with few alternatives in advanced treatment lines. To direct treatment decisions by drug sensitivity testing (DST), this study compared several methods for tumor cell isolation from malignant effusions, pointing to repeated CD45+ cell depletion for effective ...
Navit Mooshayef, Hana Barhom, Sumit Chatterji, Netta Hecht, Oran Warhaftig, Iris Kamer, Oranit Zadok, Jair Bar, Limor Broday, Amir Onn, Michael Peled   +10 more
wiley   +1 more source

Interdisciplinarity at the nexus of biomedical science training: The R3 Center for Innovation in Science Education. [PDF]

iScience
Ciubotariu II, Kobayashi T, Neely CJ, Tawia Hagan DF, Ewusi-Mensah D, Van Vactor D, Whipple EC, Camacho E, Ghosh G, Lamb HM, Owusu-Frimpong I, Alltop J, Romano JD, Kelly K, Rogers LS, Morales L, Seibel M, Rao R, Bekka S, Mills WT, Casadevall A, Bosch G.   +21 more
europepmc   +1 more source

Cytomegalovirus infection is common in prostate cancer and antiviral therapies inhibit progression in disease models

Molecular Oncology, EarlyView.
Human cytomegalovirus infection is common in normal prostate epithelium, prostate tumor tissue, and prostate cancer cell lines. CMV promotes cell survival, proliferation, and androgen receptor signaling. Anti‐CMV pharmaceutical compounds in clinical use inhibited cell expansion in prostate cancer models in vitro and in vivo, motivating investigation ...
Johanna Classon, Moa Stenudd, Margherita Zamboni, Kanar Alkass, Carl‐Johan Eriksson, Lars Pedersen, Alrik Schörling, Anna Thoss, Anders Bergh, Pernilla Wikström, Hans‐Olov Adami, Henrik Toft Sørensen, Henrik Druid, Jonas Frisén   +13 more
wiley   +1 more source

Evaluating the potential of phenotypic age to enhance cardiovascular risk prediction over chronological age in the UK Biobank. [PDF]

Sci Rep
Kwan KJS, Xie SS, Li HL, Lin XG, Lu YJ, Chen B, Ge KX, Tang SY, Zhang H, Jiang S, Tang JD.   +10 more
europepmc   +1 more source

Implications of increased carbon supply for the global expansion of jellyfish blooms [PDF]

, 2011
Brotz, Lucas, Condon, Rob, Lebrato, Mario, Pitt, Kylie, Robinson, Kelly L., Sexton, Margaret, Sweetman, Andrew K.   +6 more
core   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Applying Transdisciplinary Thinking to Pastoral Livelihoods and Environments. [PDF]

Animals (Basel)
Woodford K, Lucock X, Moot D.
europepmc   +1 more source

Development and Assessment of a Horizontally Integrated Biological Sciences Course Sequence for Pharmacy Education

American Journal of Pharmaceutical Education, 2015
Amie J Dirks-Naylor, Nicholas J. Wright, Gregory L. Alston   +2 more
semanticscholar   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

Clarity Amidst Ambiguity: Towards Precise Definitions in Biological-Informed Disciplines for Enhanced Communication. [PDF]

Biomimetics (Basel)
Huber T, Müssig J.
europepmc   +1 more source