Results 211 to 220 of about 399,799 (281)

Risk factors for lung metastasis in children and adolescent patients with papillary thyroid cancer: A retrospective cohort study. [PDF]

Endocrine
Li H, Wang L, Zhang G, Zhao Y, Kong X, Yang H, Fu X, Li P, Huang R, Liu J, Wang X, Li Z, Luo H.   +12 more
europepmc   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

FEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng, Souvik Datta, Derrick R. Samuelson   +2 more
wiley   +1 more source

Leveraging Artificial Intelligence in Drug and Biological Product Development: An FDA and Clinical Trial Transformation Initiative Workshop Report. [PDF]

NEJM AI
Poddar A, Samson M, Innes GK, Liu Q, Saha A, Hanger M, Franzetti K, ElZarrad MK, Fakhouri TH.   +8 more
europepmc   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Human cGAS Drives LINE-1 Transcriptional Activation to Trigger MAVS-Dependent Cellular Senescence. [PDF]

Aging Cell
Chen Z, Chen L, Chen X, Wang H, Tang H, Zhen Z, Jiang Y, Mao Z, Chen Y.   +8 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Endurance Training in Olympic Winter Sports: A Narrative Review of the Current Literature and Future Research Priorities. [PDF]

Scand J Med Sci Sports
Sperlich B, Holmberg HC.
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

A Retrospective Career-Long and Seasonal Study of Injury Patterns in 196 Elite Swimmers: The Role of Primary Discipline and Competitive Distance. [PDF]

Scand J Med Sci Sports
Nimb SL, Holst-Christensen T, Eggers A, Rosenberg M, Kjaer M, Magnusson SP, Højfeldt G.   +6 more
europepmc   +1 more source

Using science fiction to teach science facts [PDF]

, 2012
Bowater, Laura, Bowater, Richard, Cornea, Christine, James, Helen   +3 more
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