Results 211 to 220 of about 59,519 (241)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Structural <i>vs.</i> functional specialization: distinct competitive profiles in youth male and female flatwater paddlers. [PDF]

PeerJ
Gao W, Zhu Y, Ye W, Chen J, Chen Q.
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Comparative analysis of mRNA and circRNA expression profiles and interaction networks in testicular tissues of Mongolian horses before and after sexual maturity. [PDF]

BMC Genomics
Du M, Liu Y, He Q, Zhang X, Zhao Y, Li B, Bai D, Bou G, Bao T, Wen X, Dugarjaviin M.   +10 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Multidisciplinary perspectives on artificial intelligence in aging research and education: evolving uses, ethics, and equity considerations in gerontology. [PDF]

Gerontologist
Perone AK, Abadir PM, Berlinger N, Carey JR, Guest MA, Hass ZJ, Stephan AT, Xie B.   +7 more
europepmc   +1 more source

Beyond the Eye: Sleep Fragmentation, Autonomic Dysregulation, and Mitochondrial Dysfunction as a Common Biological Soil for Meibomian Gland Pathology. [PDF]

Invest Ophthalmol Vis Sci
Lin YH, Chen JY, Chen CL.
europepmc   +1 more source

Transforming the American Academy of Microbiology for social good through scientific portfolios. [PDF]

mBio
Nguyen NK, Burckhardt RM, Bertuzzi S, Casadevall A, Sperandio V, Lennon JT.   +5 more
europepmc   +1 more source

Editorial: Plant polyphenols: new chemical and pharmacological approaches. [PDF]

Front Pharmacol
Boylan F, Kozyra M, Kukula-Koch W.
europepmc   +1 more source

How bio-inspired is your design? A transparent reporting framework. [PDF]

Commun Eng
Harvey C.
europepmc   +1 more source