Results 71 to 80 of about 309,058 (173)

Ökomorphologie : Integration von Form, Funktion und Ökologie bei der Analyse morphologischer Strukturen [PDF]

, 2008
Organisms are complex entities whose study has necessitated an increasingly reductionistic stance in modern biology (CAPLAN 1987). As a consequence, biology as a science has been split up into numerous sub-disciplines.
Betz, Oliver
core  

Autophagy in cancer and protein conformational disorders

FEBS Letters, EarlyView.
Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley   +1 more source

Biological sciences in the school matrix: the student's look at the discipline

, 2020
La escuela secundaria es una etapa crítica en la formación del individuo, que consolida los conocimientos básicos y las habilidades de los estudiantes. El objetivo educativo debe ser desarrollar la curiosidad y el gusto por el aprendizaje, practicando efectivamente las preguntas y la investigación. Por lo tanto, el estudio busca analizar la importancia
Menezes, Barbara Barbalho Pires de, Sá, Ádilla Katarinne Gonçalves e, Braga, Dan Vitor Vieira, Monte, Jose Pinheiro do, Barbosa, Maisa Fernanda dos Santos   +4 more
openaire   +1 more source

A disciplina Educação Sexual no currículo do curso de licenciatura em Ciências Biológicas da Universidade Regional do Cariri – URCA

Revista de Ensino de Biologia da SBEnBio
O objetivo deste trabalho consiste em analisar como a disciplina de Educação Sexual no currículo do curso de licenciatura em Ciências Biológicas da Universidade Regional do Cariri (URCA) se apresenta e sua implicação para a formação inicial docente. A pesquisa apresenta-se como sendo do tipo qualitativa e exploratória, face ao processo analítico tecido
Renata Maria da Silva, Alan Belizário Cruz, Antoniel dos Santos Gomes Filho, Fabiana Correia Bezerra, Cicero Magerbio Gomes Torres   +4 more
openaire   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source

Identifying network communities with a high resolution

, 2007
Community structure is an important property of complex networks. An automatic discovery of such structure is a fundamental task in many disciplines, including sociology, biology, engineering, and computer science.
A. Y. Ng, C. Elkan, D. Hand, G. W. Flake, J. Ruan, J. Ruan, Jianhua Ruan, L. Danon, L. Danon, P. N. Tan, P. O. Fjällström, S. White, Weixiong Zhang   +12 more
core   +1 more source

A stepwise emergence of evolution in the RNA world

FEBS Letters, EarlyView.
How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley   +1 more source

Modifications in FLAP's second cytosolic loop influence 5‐LOX interaction, inhibitor binding, and leukotriene formation

FEBS Letters, EarlyView.
The enzyme 5‐lipoxygenase (5‐LOX) catalyzes the first step in the biosynthesis of leukotrienes (LTs) involved in inflammatory pathophysiology. After cellular stimulation, 5‐LOX translocates to the nucleus, interacting with the 5‐LOX‐activating protein (FLAP) to form LTA4 from arachidonic acid (AA).
Erik Romp, Katharina Rataj, Stefanie König, Marcia E. Newcomer, Oliver Werz, Ulrike Garscha   +5 more
wiley   +1 more source

Brucella NyxA and NyxB dimerization enhances effector function during infection

FEBS Letters, EarlyView.
Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre, Arthur Louche, Francine C. A. Gérard, Laurent Terradot, Suzana P. Salcedo   +4 more
wiley   +1 more source

The carboxylate “gripper” of the substrate is critical for C‐4 stereo‐inversion by UDP‐glucuronic acid 4‐epimerase

FEBS Letters, EarlyView.
UDP‐glucuronic acid 4‐epimerase (UGAepi) catalyzes NAD+‐dependent interconversion of UDP‐glucuronic acid (UDP‐GlcA) and UDP‐galacturonic acid (UDP‐GalA) via C4‐oxidation, 4‐keto‐intermediate rotation, and C4‐reduction. Here, Borg et al. examined the role of the substrate's carboxylate group in the enzymic mechanism by analyzing NADH‐dependent reduction
Annika J. E. Borg, Laura De Cnop, Bernd Nidetzky   +2 more
wiley   +1 more source