Results 71 to 80 of about 62,914 (286)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Gender Performance Gaps Across Different Assessment Methods and the Underlying Mechanisms: The Case of Incoming Preparation and Test Anxiety

Frontiers in Education, 2019
A persistent “gender penalty” in exam performance disproportionately impacts women in large introductory science courses, where exam grades generally account for the majority of the students' assessment of learning.
Shima Salehi, Sehoya Cotner, Samira M. Azarin, Erin E. Carlson, Michelle Driessen, Vivian E. Ferry, William Harcombe, Suzanne McGaugh, Deena Wassenberg, Azariah Yonas, Cissy J. Ballen   +10 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Lesson Plan Proposal on Molecular Paleontology for insertion in the discipline of Paleontology of undergraduate courses in Biological Sciences

, 2021
Molecular Paleontology has not been included in the syllabus of the discipline of Paleontology in undergraduate courses in Biological Sciences. However, if inserted in the discipline's Teaching Plan, Molecular Paleontology could bring future biologists closer to Paleobiology, a field of research that is practically unexplored in Brazil.
Alves, Everton Fernando, Machado, Marcio Fraiberg   +1 more
openaire   +1 more source

Positive results receive more citations, but only in some disciplines

, 2013
Negative results are commonly assumed to attract fewer readers and citations, which would explain why journals in most disciplines tend to publish too many positive and statistically significant findings.
Fanelli, Daniele; id_orcid
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Biological sciences in the school matrix: the student's look at the discipline

, 2020
La escuela secundaria es una etapa crítica en la formación del individuo, que consolida los conocimientos básicos y las habilidades de los estudiantes. El objetivo educativo debe ser desarrollar la curiosidad y el gusto por el aprendizaje, practicando efectivamente las preguntas y la investigación. Por lo tanto, el estudio busca analizar la importancia
Menezes, Barbara Barbalho Pires de, Sá, Ádilla Katarinne Gonçalves e, Braga, Dan Vitor Vieira, Monte, Jose Pinheiro do, Barbosa, Maisa Fernanda dos Santos   +4 more
openaire   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source