Results 201 to 210 of about 833,851 (294)

Mice carrying the full-length human immunoglobulin loci produce antigen-specific human antibodies with the lambda light chain

iScience
Summary: The development of antibody drugs through animal immunization typically requires the humanization of host antibodies to address concerns about immunogenicity in humans.
Kazuto Shimoya, Takashi Moriwaki, Kanako Kazuki, Akane Okada, Shigenori Baba, Yuana Masuda, Satoshi Abe, Yasuhiro Kazuki   +7 more
doaj  

Development of 4T1 breast cancer mouse model system for preclinical carbonic anhydrase IX studies

FEBS Open Bio, EarlyView.
Carbonic anhydrase IX (CAIX) is a well‐recognised therapeutic target and prognostic biomarker in cancer. We developed and characterised a robust murine breast cancer model system that is suitable for CAIX studies in vitro and in vivo—it comprises both CAIX‐positive and CAIX‐negative controls and provides a solid platform for the comprehensive ...
Zane Kalniņa, Ilva Liekniņa, Svetlana Koteloviča, Ramona Petrovska, Gediminas Žvinys, Agne Petrosiute, Asta Zubrienė, Matīss Toms Laugalis, Vendija Skeltona, Juris Jansons, Madara Kreishmane, Edita Čapkauskaitė, Daumantas Matulis, Kaspars Tārs   +13 more
wiley   +1 more source

Editorial: Five grand challenges in toxicology. [PDF]

Front Toxicol
Fadeel B, Alexander J, Antunes SC, Dalhoff K, Fritsche E, Hogberg HT, Huaux F, Oredsson S, Pietroiusti A, Svingen T, Wilks MF.   +10 more
europepmc   +1 more source

GDP‐fucose transporter SLC35C1: a potential regulatory role in cytosolic GDP‐fucose and fucosylated glycan synthesis

FEBS Open Bio, EarlyView.
The inactivation of SLC35C1 (GDP‐fucose transporter) and enzymes involved in GDP‐fucose biosynthesis was studied. Fucose supplementation increases the level of GDP‐fucose to abnormal, millimolar values in the absence of the TSTA3 protein and SLC35C1 in contrast to the GMDS/SLC35C1 double mutant.
Edyta Skurska, Mariusz Olczak
wiley   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Editorial: Women in nanotoxicology 2023-2024. [PDF]

Front Toxicol
Lynch I, Ghosh I.
europepmc   +1 more source

Monte Carlo modeling of radiation dose from radiation therapy with superficial x‐rays

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Superficial x‐rays (50–100 kVp) are used for treating non‐melanoma skin cancer and intraoperative radiation therapy (IORT). At these energies, the photoelectric effect significantly increases absorbed dose to bone compared to soft tissue.
Reham Barghash, Tiffany W. Martin, Amber R. Prebble, Del Leary   +3 more
wiley   +1 more source

Exposomics: a review of methodologies, applications, and future directions in molecular medicine. [PDF]

EMBO Mol Med
Wan M, Simonin EM, Johnson MM, Zhang X, Lin X, Gao P, Patel CJ, Yousuf A, Snyder MP, Hong X, Wang X, Sampath V, Nadeau KC.   +12 more
europepmc   +1 more source

Dosimetric effect of silicone‐based gel on skin surface during volumetric modulated arc therapy for breast cancer

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose This study aims to quantify and compare the dosimetric effects of varying thicknesses of StrataXRT, a silicone‐based gel, and other topical agents on the skin surface during volumetric modulated arc therapy (VMAT) for breast cancer.
Tenyoh Suzuki, Shingo Ohira, Mami Ogita, Takeshi Ohta, Yuki Nozawa, Masanari Minamitani, Takuya Hayashi, Shigeki Saegusa, Toshikazu Imae, Tsuyoshi Ueyama, Atsuto Katano, Hideomi Yamashita, Weishan Chang, Keiichi Nakagawa   +13 more
wiley   +1 more source

Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics. [PDF]

Front Toxicol
Wu X, Leung T, Jima DD, Iyangbe M, Bang J.   +4 more
europepmc   +1 more source