Results 221 to 230 of about 1,326,546 (323)

SeqExpressionAnalyser: An R Package for Automated End-to-End RNA-Seq Analysis From Reads to Differential Expression. [PDF]

Bioinform Biol Insights
Esskhayry S, Kaissi O, Radouani F, Maamar J, Karret A, Chahboune R, Fissoune R, Lamzouri A.   +7 more
europepmc   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Editorial: Cellular contributors and consequences of protein misfolding and aggregation. [PDF]

Front Mol Biosci
Arunagiri A, Sontag E, Kohler V, Venkatesan A.   +3 more
europepmc   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Emerging trends in genome integration tools for precision engineering of diverse bacterial species. [PDF]

Synth Biol (Oxf)
Rohmat RKW, Irvine TCT, Hina-Nilesh Joshi S, Bailey AM, Jenkins C, Ulaeto D, Buscaill P, Gorochowski TE.   +7 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source

MiMeDB 2.0: the Human Microbial Metabolome Database for 2026. [PDF]

Nucleic Acids Res
Kruger R, Oler E, Saha S, Poelzer J, Han S, Punsalan MP, Green B, Bushra F, Kyes M, Disu F, Wakoli J, Woudstra R, Tejol E, Fakutan O, Wang F, Lee BL, Sajed T, Tian S, Torres-Calzada C, Berjanskii M, MacKay S, Karu N, Kadurrah-Daouk R, Wishart DS.   +23 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Harnessing Large Cohorts and AI to Bridge Genomic Discovery and Clinical Practice. [PDF]

Genomics Proteomics Bioinformatics
Zhong B, Wang S, Jing X, Patel AP, Zhao Y, Wang M.   +5 more
europepmc   +1 more source