Results 221 to 230 of about 16,494,787 (294)

Phosphoinositides and inositol phosphates-functions and cellular dynamics. [PDF]

FEBS Lett
Rao F, Haucke V.
europepmc   +1 more source

RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells

FEBS Open Bio, EarlyView.
RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour, Christine Volmert, Valentina Piano   +2 more
wiley   +1 more source

Predicting transcriptional regulators in plants in the era of artificial intelligence. [PDF]

Curr Opin Plant Biol
Ko DK, Brandizzi F.
europepmc   +1 more source

Versatile vector tools for efficient protein screening across multiple expression systems

FEBS Open Bio, EarlyView.
A unified vector toolkit enables rapid protein expression screening across E. coli, insect, and mammalian cells. A single primer pair amplifies the target gene, which is inserted into any vector via a standardized interface. This streamlined workflow eliminates repeated cloning steps, accelerating the identification of optimal expression conditions for
Zhimin Zhu, Yaqing Liu, Lei Qin, Feng Yu, Qisheng Wang, Yahui Liu   +5 more
wiley   +1 more source

Strengthening global biosecurity for synthetic nucleic acid technology: from sequence screening to risk-based governance in the AI era. [PDF]

Front Bioeng Biotechnol
Kato SE, Ndudzo A, Bayiga SO, Brenda N, Serwaa C, Baluku E, Mang'anda H, Peter JJ, Shamirah K, Perez M, Tawiah RN, Anguzu S, Malemia S.   +12 more
europepmc   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Advancing cross-domain integration and semantic technologies: proceedings of the 19th international symposium on integrative bioinformatics. [PDF]

J Integr Bioinform
Ebeling MA, Lange M, Weise S, Scholz U.
europepmc   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Advancing FAIR data towards comparable, organized, predictive AI-ready data for community validation. [PDF]

Commun Biol
Wood-Charlson EM, Åkerström WN, Anderson L, Borton MA, Burley SK, Byers N, Chandramouliswaran I, Costes SV, Dehal PS, Doktycz M, Eloe-Fadrosh E, Henry C, Fagnan K, Fiehn O, Halappanavar M, Hurwitz B, Joachimiak MP, Jungbluth S, Koblitz J, Mahmud G, McCue LA, Metz TO, Mouncey N, Mungall CJ, Nelson TM, Skye V, Saravia-Butler AM, Saripalli VR, Tringe SG, Van Den Bossche T, Arkin AP.   +30 more
europepmc   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source