Results 91 to 100 of about 45,085 (268)
USP35 Acts as a Deubiquitinating Enzyme for ID3 to Promote Immune Escape in Colorectal Cancer
Advanced Science, EarlyView.USP35 stabilizes ID3 expression by deubiquitinating the K2/K30 site, thereby upregulating PD‐L1 and promoting immune escape in colorectal cancer. IU1, an inhibitor of USP35 enzyme activity, has been shown to inhibit USP35, thereby accelerating ID3 degradation, enhancing CD8+ T cell killing, and reversing the immunosuppressive microenvironment ...
Wenxin Chen +9 more
wiley +1 more source
[The biological specimen bank: methodological and organizational problems].
Annali dell'Istituto superiore di sanita, 1993 Little experience is available to solve methodological and organizational problems when setting up a biological specimen bank as a support to prospective studies on chronic diseases. Sample aliquots preparation, processing procedures and storage system are discussed in the present paper. Problems related to the quality of biological material stored, as
openaire +1 more source
Marine Flora and Fauna of the Northeastern United States Echinodermata: Crinoidea [PDF]
, 1990 The crinoid fauna of the continental margin (0-1500 m) of northeastern North America (Georgia to Canada) includes 14 species in 13 genera and 5 families. We introduce the external morphology and natural history of crinoids and include a glossary of terms,
Dearborn, John H., Messing, Charles G.
core +1 more source
Heptageniidae (Ephemeroptera) of Wisconsin [PDF]
, 2017 (excerpt) Heptageniidae are one of the most abundant and widespread components of Wisconsin\u27s aquatic insect fauna. In almost any stream with a firm substrate and free of gross pollution, the flattened nymphs can be found hiding in crevasses and under
Flowers, R. Wills, Hilsenhoff, William L
core +3 more sources
Advanced Science, EarlyView.This study identifies TOPK as a dual‐function target in gastric cancer: it drives tumor cell proliferation and migration, and under IFN‐γ stimulation, phosphorylates eIF4F complex component eIF4A1 to enhance STAT1 mRNA translation, thereby promoting PD‐L1/IDO1‐mediated tumor immunometabolic evasion.
Junbing Chen +16 more
wiley +1 more source
Journal of Blood Medicine, 2012 Carlo PetriniItalian National Institute of Health, Rome, ItalyAbstract: This article considers some of the ethical and legal issues relating to the ownership and use – including for commercial purposes – of biological material and ...
Petrini C
doaj
Summer Ephemeroptera, Plecoptera and Trichoptera of Southwestern of 15 Drainages in Great Smoky Mountains National Park [PDF]
, 2004 INHS Technical Report prepared for unspecified ...
DeWalt, R. Edward
core
Dead Matter, Living Machines: Repurposing Crustaceans' Abdomen Exoskeleton for Bio‐Hybrid Robots
Advanced Science, EarlyView.Crustacean exoskeletons, repurposed from food waste, are engineered into sustainable bending actuators combining biotic structure with synthetic control. The augmented exoskeletons achieve rapid and robust motion with lightweight body and can be used as part of robotic manipulators, grippers and swimmers.
Sareum Kim, Kieran Gilday, Josie Hughes
wiley +1 more source
Advanced Science, EarlyView.A hyaluronic acid methacrylate (HAMA) hydrogel incorporating DNA tetrahedrons loaded with Asiatic acid (TDN@AA) was developed. HM‐TDN@AA promotes angiogenesis of endothelial cells (ECs), inhibits osteoclastogenesis from bone marrow–derived macrophages (BMDMs), and enhances osteogenesis of mesenchymal stem cells (MSCs) via STAT3‐mediated mitochondrial ...
Yiwen Huang +9 more
wiley +1 more source
Advanced Science, EarlyView.Cytoplasmic RNF32 fuels CRC liver metastasis by degrading GSK3β, which stabilizes β‐catenin and activates Wnt/EMT. Moreover, RNF32 rewires the metastatic niche: it depletes CD8+/CD4+ T and NK cells while recruiting SPP1+ macrophages (which boost tumor stemness via CD44), fibroblasts, and immunosuppressive monocytes to aid colonization.
Hongyu Wang +12 more
wiley +1 more source