Results 51 to 60 of about 795,490 (279)

The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network’s first protocol: deep phenotyping in three sub-Saharan African countries

Reproductive Health, 2020
Background The PRECISE (PREgnancy Care Integrating translational Science, Everywhere) Network is a new and broadly-based group of research scientists and health advocates based in the UK, Africa and North America.
Peter von Dadelszen, Meriel Flint-O’Kane, Lucilla Poston, Rachel Craik, Donna Russell, Rachel M. Tribe, Umberto d’Alessandro, Anna Roca, Hawanatu Jah, Marleen Temmerman, Angela Koech Etyang, Esperança Sevene, Paulo Chin, Joy E. Lawn, Hannah Blencowe, Jane Sandall, Tatiana T. Salisbury, Benjamin Barratt, Andrew H. Shennan, Prestige Tatenda Makanga, Laura A. Magee, the PRECISE Network   +21 more
doaj   +1 more source

Evaluating performance in three-dimensional fluorescence microscopy [PDF]

, 2007
In biological fluorescence microscopy, image contrast is often degraded by a high background arising from out of focus regions of the specimen. This background can be greatly reduced or eliminated by several modes of thick specimen microscopy, including ...
Chong F.K., Conchello J.A., Patterson G.H., Sandison D.R., Sandison D.R., Shapiro H.M., Tsien R.Y.   +6 more
core   +3 more sources

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

X-ray phase contrast imaging of biological specimens with tabletop synchrotron radiation [PDF]

, 2011
Since their discovery in 1896, x-rays have had a profound impact on science, medicine and technology. Here we show that the x-rays from a novel tabletop source of bright coherent synchrotron radiation can be applied to phase contrast imaging of ...
Alexander G. R. Thomas, Anatoly Maksimchuk, Charlotte A. J. Palmer, Chris McGuffey, Franklin Dollar, Galina Kalintchenko, Joerg Schreiber, Karl Krushelnick, Michael S. Bloom, Stefan Kneip, Stuart P. D. Mangles, Takeshi Matsuoka, Victor Yanovsky, Vladimir Chvykov, Will Schumaker, Zulfikar Najmudin   +15 more
core   +2 more sources

Methanol immersion reduces spherical aberration of water dipping lenses at long wavelengths used in multi-photon laser scanning microscopy [PDF]

, 2012
Dipping objectives were tested for multi-photon laser scanning microscopy, since their large working distances are advantageous for thick specimens and the absence of a coverslip facilitates examination of living material.
Bestvater, Bolin, Booth, Booth, Cahalan, Demenikov, Denk, Débarre, Débarre, Ganic, Hell, Helmchen, Jacobsen, Ji, Kao, Mann, Marsh, Neil, Norris, Rueckel, Saavedra, Sheppard, Sheppard, Sheppard, Sheppard, Tang, Theer, Wan, Wilson   +28 more
core   +1 more source

Are geometric morphometric analyses replicable? Evaluating landmark measurement error and its impact on extant and fossil Microtus classification. [PDF]

, 2020
Geometric morphometric analyses are frequently employed to quantify biological shape and shape variation. Despite the popularity of this technique, quantification of measurement error in geometric morphometric datasets and its impact on statistical ...
Adams D. C., Arnqvist G., Cardini A., Chapman R. E., Fox N. S., Patterson B. D., Rohlf F. J., Rohlf F. J., Zelditch M.   +8 more
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

The bumble bees (Hymenoptera: Apidae: Bombus) of Arkansas, fifty years later [PDF]

, 2015
Many species of bumble bees (Hymenoptera: Apidae: Bombus Latreille) are declining throughout their ranges in North America, yet detecting population trends can be difficult when historical survey data are lacking.  In the present study, contemporary data
Szalanski, Allen L., Tripodi, Amber D.
core   +2 more sources

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source