Results 121 to 130 of about 3,202,429 (316)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Chemical and biological responses of marl lakes to eutrophication

, 2014
Eutrophication remains one of the foremost environmental issues threatening the quality of surface waters yet comparatively little is known of the timing, magnitude and characteristics of nutrient-related changes in highly calcareous (marl) lakes.  ...
Carl D Sayer; UCL, Helen Bennion; UCL, Emma Wiik; UCL, Nigel J Willby; University of Stirling   +3 more
core  

Investigation of the Biosafety of Antibacterial Mg(OH)₂ Nanoparticles to a Normal Biological System. [PDF]

J Funct Biomater, 2023
Wang Y, Liu Y, Li X, Wang F, Huang Y, Liu Y, Zhu Y.   +6 more
europepmc   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

On engineering reliability concepts and biological aging [PDF]

Some stochastic approaches to biological aging modeling are studied. We assume that an organism acquires a random resource at birth. Death occurs when the accumulated dam-age (wear) exceeds this initial value, modeled by the discrete or continuous random
Maxim S. Finkelstein
core  

The Biological and Regulatory Role of Type VI Secretion System of Klebsiella pneumoniae

, 2023
Wenke Liu,1,* Min Li,1,* Shiwen Cao,1 Hafiz Muhammad Ishaq,2 Huajie Zhao,1 Fan Yang,1 Liang Liu1 1Department of Pathogenic Biology, School of Basic Medical Sciences, Xinxiang Medical University, Xinxiang, People’s Republic of China; 2Faculty of ...
Ishaq HM, Liu L, Cao S, Li M, Yang F, Liu W, Zhao H   +6 more
core  

A curated gene and biological system annotation of adverse outcome pathways related to human health. [PDF]

Sci Data, 2023
Saarimäki LA, Fratello M, Pavel A, Korpilähde S, Leppänen J, Serra A, Greco D.   +6 more
europepmc   +1 more source

Biological Systems [PDF]

Science, 1988
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Enhanced Biomass and Protein Synthesis in Engineered Cyberlindnera jadinii Growing on Ethanol/Acetate: Metabolic Engineering and Transcriptomic Mechanism

Foods
Producing single-cell protein (SCP) from syngas-derived ethanol and acetate offers a sustainable solution to global protein shortages, yet microbial utilization mechanisms for these mixtures remain underexplored.
Yixin Cao, Longxue Ma, Yaxiang Li, Zhen Zhu, Yu Duan, Wenqin Bai, Liucheng Long, Pengbao Shi, Limei Chen, Demao Li   +9 more
doaj   +1 more source