Results 221 to 230 of about 30,599,032 (364)

Embryo-derived teratoma in vitro biological system reveals antitumor and embryotoxic activity of valproate. [PDF]

FEBS J, 2020
Plazibat M, Katušić Bojanac A, Himerleich Perić M, Gamulin O, Rašić M, Radonić V, Škrabić M, Krajačić M, Krasić J, Sinčić N, Jurić-Lekić G, Balarin M, Bulić-Jakuš F.   +12 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Cellular and epigenetic perspective of protein stability and its implications in the biological system. [PDF]

Epigenomics
Manav N, Jit BP, Kataria B, Sharma A.
europepmc   +1 more source

Biological Identifications Through DNA Barcodes

, 2012
H. Ramadan, N. Baeshen
semanticscholar   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Stochastic biological system-of-systems modelling for iPSC culture. [PDF]

Commun Biol
Zheng H, Harcum SW, Pei J, Xie W.
europepmc   +1 more source

Retraction Notice: Multi-Objective Optimization Algorithm and Preference Multi-Objective Decision-Making Based on Artificial Intelligence Biological Immune System

Juan Bao, Xiangyang Liu, Zhengtao Xiang, Wei Gang   +3 more
openalex   +1 more source

UnifiedGreatMod : A New Holistic Modeling Paradigm for Studying Biological Systems on a Complete and Harmonious Scale [PDF]

Riccardo Aucello, Simone Pernice, Dora Tortarolo, Raffaele Calogero, Celia Herrera-Rincon, Giulia Ronchi, Stefano Geuna, Francesca Cordero, Píetro Lió, Marco Beccuti   +9 more
openalex   +1 more source

Advancing Multi-Scale Simulation Methods for Biological Membrane Systems [PDF]

, 2019
Astrid F. Brandner, Štěpán Timr, Simone Melchionna, Philippe Derreumaux, Marc Baaden, Fabio Sterpone   +5 more
openalex   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source