Results 261 to 270 of about 30,599,032 (364)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Biological Treatment of Second Cheese Whey Using Marine Microalgae/Cyanobacteria-Based Systems [PDF]

Stefania Patsialou, I TSAKONA, Dimitris V. Vayenas, Athanasia G. Tekerlekopoulou   +3 more
openalex   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A modified particle swarm optimization algorithm for parameter estimation of a biological system. [PDF]

Theor Biol Med Model, 2018
Mosayebi R, Bahrami F.
europepmc   +1 more source

Innate immune pattern recognition: a cell biological perspective.

Annual Review of Immunology, 2015
Sky W. Brubaker, K. Bonham, I. Zanoni, Jonathan C. Kagan   +3 more
semanticscholar   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Scalable nonlinear programming framework for parameter estimation in dynamic biological system models. [PDF]

PLoS Comput Biol, 2019
Shin S, Venturelli OS, Zavala VM.
europepmc   +1 more source

Structural and molecular interrogation of intact biological systems

Nature, 2013
Kwanghun Chung, Jenelle L. Wallace, Sung-Yon Kim, Sandhiya Kalyanasundaram, A. Andalman, Thomas J. Davidson, J. J. Mirzabekov, K. Zalocusky, J. Mattis, A. Denisin, Sally Pak, Hannah Bernstein, C. Ramakrishnan, L. Grosenick, V. Gradinaru, K. Deisseroth   +15 more
semanticscholar   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

The plant immune system

Nature, 2006
Jonathan D. G. Jones, Jeffery L Dangl
semanticscholar   +1 more source