Results 181 to 190 of about 3,876,466 (316)

Annual Report - Marine Biological Laboratory, 1896-1902

open access: yes, 1902
Annual report of the Marine Biological Laboratory in Woods Hole for the years 1896-1899.
Marine Biological Laboratory (Woods Hole MA)
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

NMR and compartmentation in biological tissues

open access: yesProgress in Nuclear Magnetic Resonance Spectroscopy, 1985
Belton, P, Ratcliffe, R
openaire   +1 more source

Annual Report - Marine Biological Laboratory, 1948

open access: yes, 1948
Annual report of the Marine Biological Laboratory in Woods Hole. 1948.
Marine Biological Laboratory (Woods Hole MA)
core  

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Annual Report - Marine Biological Laboratory, 1952

open access: yes, 1952
Annual report of the Marine Biological Laboratory in Woods Hole. 1952.
Marine Biological Laboratory (Woods Hole MA)
core  

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

open access: yesMolecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park   +6 more
wiley   +1 more source

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