Results 171 to 180 of about 1,074,318 (296)

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Cross-scale design of abiotic-biotic interfaces for semi-artificial photosynthesis. [PDF]

Chem Sci
Wang H, Li J, Feng Y, He D, Fan X, Wang B, Cai Z, Zeng C, Xiao K.   +8 more
europepmc   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Physical activity for public health in the 21st century. [PDF]

Nat Med
Salvo D, Crochemore-Silva I, Wendt A, Tarp J, Shiroma EJ, Simpson RJ, Lee IM, Ekelund U, Cerin E, Keita Y, Bauman A, Hallal PC, Ramirez Varela A, Pratt M, Reis R, Hinckson E, Ding D, Kohl HW, Sallis J.   +18 more
europepmc   +1 more source

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons. [PDF]

Cell Death Dis
Blackburn E, Birsa N, Lopes AT, Fisher EMC, Lazo OM, Schiavo G.   +5 more
europepmc   +1 more source

Translocation across biological membranes: activity, structure and regulation of transporters

, 2017
Alle cellen zijn omsloten door biologische membranen met selectief doorlatende membrane, die het mogelijk maken om omstandigheden "binnen" en "buiten" de cel te handhaven. De gereguleerde beweging van moleculen door deze membranen is nodig voor talrijke essentiële processen, waaronder het verkrijgen van voedingsstoffen, het regelen van de concentratie ...
openaire   +1 more source

On Accumulation and Active Transport in Biological Systems. I. Thermodynamic Considerations. [PDF]

Acta Chemica Scandinavica, 1948
Thomas Rosenberg, Monica Johanson
openaire   +1 more source

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source