Results 171 to 180 of about 434,984 (314)

An investigation using cultured human cell lines, of the involvement of vanadium, cation transport and phosphatidylinositol in the aetiology of bipolar manic-depressive psychosis

, 2015
The symptoms, classification, occurrence and possible aetiologies of bipolar manic-depressive psychosis have been reviewed, with particular emphasis on the possible role of the vanadate ion (V5+) and cation transport in the illness.
Banks, Rosamonde Elizabeth, Naylor, Graham   +1 more
core  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Oscillating shear index, wall shear stress and low density lipoprotein accumulation in human RCAs

, 2011
This paper was presented at the 3rd Micro and Nano Flows Conference (MNF2011), which was held at the Makedonia Palace Hotel, Thessaloniki in Greece.
Soulis, JV, Giannoglou, GD, Fytanidis, DK, Papaioannou, VC, 3rd Micro and Nano Flows Conference (MNF2011)   +4 more
core  

A rapid transfer of virions coated with heparan sulfate from the ECM to CD151 defines an early step in the human papillomavirus infection cascade. [PDF]

Elife
Massenberg A, Homsi Y, Schneider CN, Mikuličić S, Döring T, Florin L, Lang T.   +6 more
europepmc   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

ABC pumps and their role in active drug transport

, 2009
Pharmacokinetic limitations affect drug bioavailability determining the loss or the reduction of the pharmacological effects. The Gastro Intestinal tract (GI) and the Blood Brain Barrier (BBB) are the most important restrictive and selective ...
COLABUFO, Nicola Antonio, NISO M, PERRONE, Roberto, BERARDI, Francesco, CONTINO, MARIALESSANDRA   +4 more
core  

A Microfluidic Framework for Neuroprotective Compound Triage Across Ischemia and Neurodegeneration. [PDF]

Molecules
Anchimowicz J, Jakiela S.
europepmc   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

On Accumulation and Active Transport in Biological Systems. I. Thermodynamic Considerations. [PDF]

Acta Chemica Scandinavica, 1948
Thomas Rosenberg, Monica Johanson
openaire   +1 more source

Nature-Inspired Solutions: Biomimetic Materials and Adaptive Devices for Precision Urinary Oncology. [PDF]

Cancers (Basel)
Zhong C, Yin L, Hung M, Yao S, Tang M, Cong Z.   +5 more
europepmc   +1 more source