Results 231 to 240 of about 1,765,133 (301)

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Human Organoids and Organ-on-Chip for Biotoxin Assessment: Applications, Best Practices, and a Translational Roadmap. [PDF]

Toxins (Basel)
Li M, Huang S, Jia J, Feng Y, Zhang J.
europepmc   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Sources of non-Arrhenius electron transport in bacterial nanowires.

Phys Chem Chem Phys
Terai K, Zhang P, Beratan DN.
europepmc   +1 more source

Impaired BDNF-TrkB trafficking and signalling in Down syndrome basal forebrain neurons. [PDF]

Cell Death Dis
Blackburn E, Birsa N, Lopes AT, Fisher EMC, Lazo OM, Schiavo G.   +5 more
europepmc   +1 more source

HACCP-compatible ear acupuncture using biodegradable starch-based needles mitigates transport-induced physiological and oxidative stress in calves. [PDF]

Vet World
Sato S, Kanno C, Hoshi Y, Yamato O, Ijiri M, Miura H, Ono HK, Takahashi F, Kawaguchi H.   +8 more
europepmc   +1 more source

CATION AMINO ACID TRANSPORTER1 encodes an arginine transporter whose expression is influenced by daylength and Photoperiod-1. [PDF]

Ann Bot
Pasquariello M, Qu Y, Gauley A, Bentham A, Dixon LE, Boden SA.   +5 more
europepmc   +1 more source

SR-B1-Mediated Transplacental Transfer of Hydrophobic Toxicants Disrupts Fetal Development During Barriergenesis. [PDF]

Adv Sci (Weinh)
Huang Y, Shang H, Jiao L, Chen C, Liu Z, Yang Y, Zhang Q, Tang S, Jia X, Yang H, Wan Y.   +10 more
europepmc   +1 more source