Results 301 to 310 of about 6,440,735 (362)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Selective ion transport of nonlinear resistive switching by hierarchical nanometer-to-angstrom channels for nanofluidic transistors. [PDF]

Sci Adv
Hu X, Xu H, Lu J, Cui F, Wu HA, Wang F, Jiang L, Novoselov KS, Wang H.   +8 more
europepmc   +1 more source

Compounds having aromatic rings and side-chain amide-functionality and a method for transporting monovalent anions across biological membranes using the same

, 2008
Jeffery T. Davis, Vladimir Sidorov, Frank W. Kotch   +2 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Making sense of low-complexity domains: The 2025 Lasker Basic Science Award. [PDF]

Proc Natl Acad Sci U S A
Kaelin WG.
europepmc   +1 more source

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Auxin Gradients Determine Reproductive Development in Pea (Pisum sativum). [PDF]

Physiol Plant
Adihetty DD, Kaur H, Jayasinghege CPA, Reinecke DM, Ozga JA.   +4 more
europepmc   +1 more source

Anisotropic light propagation in human brain white matter. [PDF]

Neurophotonics
Pini E, Di Meo D, Costantini I, Sorelli M, Bradley S, Wiersma DS, Pavone FS, Pattelli L.   +7 more
europepmc   +1 more source

Characterizing Solute Transport Across Cell Layers: Artifact Correction and Parameter Extraction from a Simplified Three-Compartment Model

Tárnoki-Zách J, Boldizsár I, Kovács GM, Döme B, Bősze S, Czirók A.   +5 more
europepmc   +1 more source

The relationship between components of the biosafety incident response competence for clinical nursing staff: a network analysis. [PDF]

BMC Psychiatry
Wu C, Zha N, Zhang K, He S, He J, Fu M, Zhang X, Lang H.   +7 more
europepmc   +1 more source