Results 231 to 240 of about 158,581 (292)

A Bifunctional Small Molecule Degrader of the Long Noncoding RNA MALAT1 Triplex

Chemistry – A European Journal, Volume 32, Issue 15, 22 April 2026.
Targeting disease‐linked RNAs with small molecules is often limited by the modest impact of binding RNA structure alone. Here, we present a first‐in‐class bifunctional molecule that degrades the oncogenic lncRNA MALAT‐1 by inducing proximity between the RNA and a cleaving warhead.
Christian A. T. Brega, Benjamin A. Craig, Sigitas Mikutis, Rupert S. J. Proctor, Yuliia Vyborna, Galway Ivey, Maria Eleftheriou, Kostas Tzelepis, Mo Yang, Shaifaly Parmar, Javier Bonet‐Aleta, John S. Schneekloth Jr., Gonçalo J. L. Bernardes   +12 more
wiley   +1 more source

Thyroid doses estimated for a cohort of people exposed to fallout from atmospheric nuclear weapons testing at the semipalatinsk nuclear test site, Kazakhstan. [PDF]

Radiat Environ Biophys
Drozdovitch V, Lipikhina A, Apsalikov K, Brait Y, Tokanov A, Yessilkanov G, Rosenson R, Bouville A, Ostroumova E.   +8 more
europepmc   +1 more source

From Mechanisms to Materials: Oximate Reactivity and Emerging Strategies for Organophosphate Detoxification

ChemPhysChem, Volume 27, Issue 7, 14 April 2026.
The development of effective strategies for the detoxification of organophosphorus (OP) nerve agents has evolved from the early mechanistic studies of François Terrier and collaborators, who first elucidated the exceptional nucleophilicity of α‐effect species such as oximes and hydroxamates, to the modern design of supramolecular and material‐based ...
Pedro Rodríguez‐Dafonte
wiley   +1 more source

A critical reassessment of the novel weapons hypothesis and allelopathy as an adaptive strategy that facilitates plant invasion. [PDF]

New Phytol
Colautti RI, Antunes PM.
europepmc   +1 more source

The urgent need for biosecurity education within the agribusiness sector. [PDF]

Front Microbiol
Ibbotson O, Shang L.
europepmc   +1 more source

Awareness of the dual-use dilemma in scientific research: reflections and challenges to Latin America. [PDF]

Front Bioeng Biotechnol
Flores-Coronado JA, Alanis-Valdez AY, Herrera-Saldivar MF, Flores-Flores AS, Vazquez-Guillen JM, Tamez-Guerra RS, Rodriguez-Padilla C.   +6 more
europepmc   +1 more source

Chemical Warfare Through the Ages: A Systematic Review From Antiquity to the Present. [PDF]

J Toxicol
Honeyman DA, Heslop DJ, Lim S, MacIntyre CR.   +3 more
europepmc   +1 more source

Preparedness of Emergency Room Nurses for Bioterrorism Based on the Health Belief Model: A Multicenter Qualitative Study. [PDF]

Int Nurs Rev
Jeon MK, Kim Y.
europepmc   +1 more source

Tularemia: Historical Perspectives and Current Challenges of a Re-Emerging Zoonosis. [PDF]

Biomedicines
Di Spirito M, Pascolini C, Salemi S, Spagnolo F, Luca V, Molinari F, Rozov O, Lista F, D'Amelio R, Fillo S.   +9 more
europepmc   +1 more source