Results 31 to 40 of about 58,179 (273)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
National Implementation Measures [PDF]
, 1998 YesArticle IV of the Biological and Toxin Weapons Convention sets out the obligation for States Parties to implement the BTWC through appropriate national measures.
Pearson, Graham S., Sims, N.A.
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Advanced Science, EarlyView.Soybean employs its circadian clock, governed by GmCCA1, to rhythmically defend against soybean cyst nematodes. The pathogen retaliates by secreting the effector Hg4E02, which hijacks the clock to suppress defense and co‐opt the host's translation machinery for nutrient acquisition.
Xingwei Wang +21 more
wiley +1 more source
Вестник войск РХБ защиты, 2023 The Convention on the prohibition of the development, production, stockpiling and use of chemical weapons and on their destruction (CWC) stipulates the realization of the detailed procedure for the verification of the implementation of all its provisions,
I. V. Rybalchenko, V. N. Fateenkov
doaj +1 more source
Biomedical Community and the Biological and Toxin Weapons Convention [PDF]
, 2001 YesNegotiations to find a legally binding way to strengthen the Biological and Toxin Weapons Convention (BTWC) of 1972 [1]are in danger of failing. The crisis was precipitated during the current round of talks, now in its final week in Geneva, when ...
Dando, Malcolm R., Whitby, Simon M.
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The Anatomical Record, EarlyView.Abstract In a large sample of adult crab‐eating macaques, we quantified sexual dimorphism in size, shape, and covariance across the whole skull and among anatomical regions of the cranium and mandible. All regions showed significant mean sex differences, but the magnitude of size and shape dimorphism varied substantially.
Andrea Cardini, Paul O'Higgins
wiley +1 more source
Introduction: Deterrence by Denial and the Long Journey of Addressing Biological Weapons Risks
Journal for Peace and Nuclear DisarmamentDeterrence by denial is a classic defense strategy in which the goal is to offset an adversary’s capabilities in ways that deny them success in achieving their intended military or strategic effects. If their modes of attack are unlikely to succeed – but
Christine Parthemore, Andy Weber
doaj +1 more source
‘Muddling Through’ in the Biological and Toxin Weapons Convention [PDF]
International Politics, 2017 The paper looks at power in the origins and evolution of the Biological & Toxin Weapons Convention (BWC). It begins by looking at the origins of what some have termed a taboo surrounding poison weapons, before turning to look at the role of different forms of power in the genesis of the BWC in the late 1960s. The article proceeds to look at the role of
openaire +1 more source
Reviewing science and technology in the context of the Biological Weapons Convention [PDF]
, 2010 There is evidence of the emergence of a consensus amongst a number of States Parties to the BWC and NGOs on the principle of changing the process of S&T review as part of the wider quinquennial review process of the BWC. However, there is little evidence
McLeish, Caitriona, Revill, James
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Prioritizing Feasible and Impactful Actions to Enable Secure AI Development and Use in Biology
Biotechnology and Bioengineering, EarlyView.ABSTRACT As artificial intelligence continues to enhance biological innovation, the potential for misuse must be addressed to fully unlock the potential societal benefits. While significant work has been done to evaluate general‐purpose AI and specialized biological design tools (BDTs) for biothreat creation risks, actionable steps to mitigate the risk
Josh Dettman +4 more
wiley +1 more source