Results 11 to 20 of about 321,951 (345)
Journal of The Royal Society Interface, 2022 The formalization of biological systems using computational modelling approaches as an alternative to mathematical-based methods has recently received much interest because computational models provide a deeper mechanistic understanding of biological systems.
Savas Konur +2 more
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Microbiology and Molecular Biology Reviews, 2007 SUMMARYColicins are proteins produced by and toxic for some strains ofEscherichia coli. They are produced by strains ofE. colicarrying a colicinogenic plasmid that bears the genetic determinants for colicin synthesis, immunity, and release. Insights gained into each fundamental aspect of their biology are presented: their synthesis, which is under SOS ...
Cascales, E. +8 more
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Synthetic biology: biology by design [PDF]
Microbiology, 2013 Synthetic biology can be defined as the design and construction of novel biologically based parts, devices and systems, as well as the redesign of existing natural biological systems, for useful purposes. It builds on genetic engineering, being design-driven genetic engineering encompassing engineering concepts of standardization and abstraction (Endy,
Roberts, MAJ +3 more
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Systems Biology, Integrative Biology, Predictive Biology [PDF]
Cell, 2005 The pursuit of science is based on empiricism enabled by advancing technologies. Theories then emerge that unify our understanding of natural order. The trinity of experimentation, theory, and technology that underlies the scientific method cannot be placed into a hierarchy of importance.
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Construction of a Plasmodium falciparum Rab-interactome identifies CK1 and PKA as Rab-effector kinases in malaria parasites [PDF]
, 2011 Background information The pathology causing stages of the human malaria parasite Plasmodium falciparum reside within red blood cells that are devoid of any regulated transport system.
Bourdoncle, P. +9 more
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Multidimensional separation prior to mass spectrometry: Getting closer to the bottom of the iceberg [PDF]
, 2013 While prefractionation has previously been shown to improve results in MS analysis, a novel combination provides an additional dimension of separation: protein fractionation by SDS-PAGE followed by IEF of tryptic peptides before separation by RP-LC ...
Mayr, Manuel, Rabilloud, Thierry
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Molecular Biology or Ultrastructural Biology ? [PDF]
Nature, 1961 IN a recent communication1, Prof. C. H. Waddington protests against the increasing use of the name ‘molecular biology’ for a large and ever-growing field to which, he argues, it does not apply, and suggests confining it to more restricted topics for which in any event a better name would be ‘ultra-structural biology’.
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Synthetic biology—putting engineering into biology [PDF]
Bioinformatics, 2006 Abstract Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we review the case for this emerging discipline.
Heinemann, Matthias, Panke, Sven
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Induced folding in RNA recognition by Arabidopsis thaliana DCL1 [PDF]
, 2015 DCL1 is the ribonuclease that carries out miRNA biogenesis in plants. The enzyme has two tandem double stranded RNA binding domains (dsRBDs) in its C-terminus.
Benoit Matthieu P. M. H. +4 more
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The case of Heinrich Wilhelm Poll (1877-1939): A German-Jewish geneticist, eugenicist, twin researcher, and victim of the Nazis [PDF]
, 2006 This paper uses a reconstruction of the life and career of Heinrich Poll as a window into developments and professional relationships in the biological sciences in Germany in the period from the beginning of the twentieth century to the Nazi seizure of ...
Braund, James, Sutton, Douglas G.
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