Results 81 to 90 of about 306,642 (296)

Quantitative prediction of intravenous drug interactions caused by cytochromes P450 inhibitors and inducers

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Background Aims Pharmacokinetic interaction studies typically focus on oral administration, but intravenous (IV) administration bypasses intestinal degradation and hepatic first‐pass metabolism, leading to distinct drug–drug interaction (DDI) magnitude. This study aimed to develop a predictive model for DDIs involving IV‐administered drugs.
Vianney Tuloup   +2 more
wiley   +1 more source

T cell-specific suppressor factor(s) with regulatory influence on interleukin 2 production and function [PDF]

open access: yes, 1982
In this study we report that alloantigen-activated spleen cells produce both amplifying and suppressive factors under the same conditions. Both types of soluble mediators--as detected in different assay systems-- were present in the supernatants of in ...
Koszinowski, Ulrich H., Kramer, M.
core  

Contraindicated drug–drug interactions and associated adverse drug reactions in an observational cohort study of 4543 paediatric hospitalized patients

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Abstract Background and Purpose Drug–drug interactions (DDIs) are associated with an increased risk of adverse drug reactions (ADRs). Hospitalized children are particularly vulnerable to DDIs and ADRs due to polypharmacy, frequent use of unlicensed or off‐label medications, and dosing regimens often extrapolated from adult data.
Emilie Laval   +6 more
wiley   +1 more source

Radiodiagnostic method for studying swimbladder inflammation caused by Anguillicola crassus (Nematoda:Dracunculoidea) [PDF]

open access: yes, 1998
The nematode Anguillicola crassus appeared in Europe about 15 yr ago, and has subsequently become recognised as a cause of major pathological lesions in the swimbladder of the European eel Anguilla anguilla. The radiographic method reported in this paper
Beregi, Attila   +3 more
core   +1 more source

A roadmap to key traits of invasive Drosophilidae

open access: yesBiological Reviews, EarlyView.
ABSTRACT Biological invasions have intensified in recent decades, mostly driven by international trade and travel, raising significant concerns, particularly regarding insect pests. Once non‐native species establish, they can disrupt natural ecosystem stability, undermine agroecosystem sustainability and cause substantial economic losses.
Gwenaëlle Deconninck   +14 more
wiley   +1 more source

Maladie rénale chronique: facteurs associes, étiologies, caractéristiques clinique et biologique à Lubumbashi en République Démocratique du Congo

open access: yesThe Pan African Medical Journal, 2017
INTRODUCTION: La maladie rénale chronique constitue un véritable problème mondial de santé publique du fait de l'augmentation de ses principaux facteurs de risque à savoir l'hypertension artérielle et le diabète sucré. Dans nos milieux à faible revenu et
Serge Muleka Ngoie   +8 more
doaj   +1 more source

Immunologische Experimente am Computer : theoretische Immunologie schließt Wissenslücken [PDF]

open access: yes, 2007
Mathematische Methoden in der Biologie haben sich in den vergangenen 25 Jahren zunehmend etabliert. Etwa in den Bereichen der Entwicklung von Organen und Organismen sind große Anstrengungen in der Mathematik unternommen worden, die grundlegenden ...
Meyer-Hermann, Michael
core  

Freely forming groups: trying to be rare [PDF]

open access: yes, 2006
A simple weakly frequency dependent model for the dynamics of a population with a finite number of types is proposed, based upon an advantage of being rare.
Bürger   +4 more
core   +3 more sources

Programming the Optoelectronic Properties of Atomically Precise Gold Nanoclusters Using the Conformational Landscape of Intrinsically Disordered Proteins

open access: yesChemistry – A European Journal, EarlyView.
ABSTRACT The rational design of hybrid nanomaterials with precisely controlled properties remains a central challenge in materials science. While atomically precise gold nanoclusters (Au‐NCs) offer molecule‐like control over a metallic core, tuning their optoelectronic behavior via surface engineering is often empirically driven.
Santiago Rodriguez   +15 more
wiley   +1 more source

Ultrastructure of calcareous dinophytes (Thoracosphaeraceae, Peridiniales) with a focus on vacuolar crystal-like particles. [PDF]

open access: yes, 2013
Biomineralization in calcareous dinophytes (Thoracosphaeracaea, Peridiniales) takes place in coccoid cells and is presently poorly understood. Vacuolar crystal-like particles as well as collection sites within the prospective calcareous shell may play a ...
Gottschling, Marc   +4 more
core   +2 more sources

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