Results 161 to 170 of about 8,594,077 (317)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Correction: Carotenuto et al. <i>Xenopus laevis</i> (Daudin, 1802) as a Model Organism for Bioscience: A Historic Review and Perspective. <i>Biology</i> 2023, <i>12</i>, 890. [PDF]

Biology (Basel)
Carotenuto R, Pallotta MM, Tussellino M, Fogliano C.   +3 more
europepmc   +1 more source

Escherichia coli in Molecular Biology and Biotechnology [PDF]

Shobith Suresh
openalex   +1 more source

The big, the bad, and the beautiful: Biology of the world's largest flowers [PDF]

, 2017
Lachezar A. Nikolov, Charles C. Davis
openalex   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Powerful Impact of Interdisciplinary Collaboration Between Societies. [PDF]

J Histochem Cytochem
Frevert CW, Schaefer L, Hewitt SM.
europepmc   +1 more source

Expression of Concern: The RSF1 Histone-Remodelling Factor Facilitates DNA Double-Strand Break Repair by Recruiting Centromeric and Fanconi Anaemia Proteins.

PLoS Biology
PLOS Biology Editors
doaj   +1 more source

Vestigial rides a fat/dachsous wave in wing development. [PDF]

PLoS Biology, 2010
PLoS Biology Editors
doaj   +1 more source

Review Of The Problem Of Life By C. U. M. Smith [PDF]

, 1977
Jenkins, John B.
core   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source