Results 181 to 190 of about 7,687,598 (369)

Integrative transcriptomic analysis identifies emetine as a promising candidate for overcoming acquired resistance to ALK inhibitors in lung cancer

open access: yesMolecular Oncology, EarlyView.
We propose an efficient strategy to suppress ALK inhibitor (ALKi) resistance. By analyzing transcriptome data, we identified emetine as a potential inhibitor. We demonstrated that emetine exhibited effectiveness in inhibiting the growth of ALKi‐resistant cells, and further interpreted its impact on the resistant signatures through drug‐induced RNA ...
Sang‐Min Park   +8 more
wiley   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

open access: yesMolecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić   +31 more
wiley   +1 more source

Hijacking the BAF complex: the mechanistic interplay of ARID1A and EWS::FLI1 in Ewing sarcoma

open access: yesMolecular Oncology, EarlyView.
Ewing sarcoma is driven by the EWS::FLI1 fusion protein, which disrupts gene expression by hijacking the BAF complex via ARID1A. ARID1A's ability to form biomolecular condensates is crucial for tumor growth, making it a potential therapeutic target. However, targeting these transient condensates is challenging, requiring further research. Ewing sarcoma,
Erich J. Sohn, David S. Libich
wiley   +1 more source

Genomic landscape and preclinical models of angiosarcoma

open access: yesMolecular Oncology, EarlyView.
Angiosarcomas are a rare and aggressive cancer with a poor prognosis for patients. The genomic landscape of angiosarcoma can be highly complex and heterogenous; however, recent studies have identified some common features especially within anatomic and molecular subgroups.
Annaleigh Benton   +3 more
wiley   +1 more source

The Morphogenesis Of Evolutionary Developmental Biology [PDF]

open access: yes, 2003
The early studies of evolutionary developmental biology (Evo-Devo) come from several sources. Tributaries flowing into Evo-Devo came from such disciplines as embryology, developmental genetics, evolutionary biology, ecology, paleontology, systematics ...
Gilbert, Scott F.
core   +2 more sources

On Volume in Biology

open access: green, 1916
Lawrence J. Henderson
openalex   +1 more source

SYMPOSIUM ON THE BIOLOGY OF BACTERIAL SPORES [PDF]

open access: bronze, 1952
O. B. Williams   +10 more
openalex   +1 more source

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