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Synthetic biology—putting engineering into biology [PDF]
Abstract Synthetic biology is interpreted as the engineering-driven building of increasingly complex biological entities for novel applications. Encouraged by progress in the design of artificial gene networks, de novo DNA synthesis and protein engineering, we review the case for this emerging discipline.
Heinemann, Matthias, Panke, Sven
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The formalization of biological systems using computational modelling approaches as an alternative to mathematical-based methods has recently received much interest because computational models provide a deeper mechanistic understanding of biological systems.
Savas Konur +2 more
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SUMMARYColicins are proteins produced by and toxic for some strains ofEscherichia coli. They are produced by strains ofE. colicarrying a colicinogenic plasmid that bears the genetic determinants for colicin synthesis, immunity, and release. Insights gained into each fundamental aspect of their biology are presented: their synthesis, which is under SOS ...
Cascales, E. +8 more
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Synthetic biology: biology by design [PDF]
Synthetic biology can be defined as the design and construction of novel biologically based parts, devices and systems, as well as the redesign of existing natural biological systems, for useful purposes. It builds on genetic engineering, being design-driven genetic engineering encompassing engineering concepts of standardization and abstraction (Endy,
Roberts, MAJ +3 more
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Systems Biology, Integrative Biology, Predictive Biology [PDF]
The pursuit of science is based on empiricism enabled by advancing technologies. Theories then emerge that unify our understanding of natural order. The trinity of experimentation, theory, and technology that underlies the scientific method cannot be placed into a hierarchy of importance.
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Molecular Biology or Ultrastructural Biology ? [PDF]
IN a recent communication1, Prof. C. H. Waddington protests against the increasing use of the name ‘molecular biology’ for a large and ever-growing field to which, he argues, it does not apply, and suggests confining it to more restricted topics for which in any event a better name would be ‘ultra-structural biology’.
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The Embryonic Transcriptome Of The Red-Eared Slider Turtle (Trachemys Scripta) [PDF]
The bony shell of the turtle is an evolutionary novelty not found in any other group of animals, however, research into its formation has suggested that it has evolved through modification of conserved developmental mechanisms.
Cebra-Thomas, J. +14 more
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[This corrects the article DOI: 10.1371/journal.pbio.3001494.].
PLOS Biology Staff
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Correction: Structure of Type IIL Restriction-Modification Enzyme MmeI in Complex with DNA Has Implications for Engineering New Specificities. [PDF]
[This corrects the article DOI: 10.1371/journal.pbio.1002442.].
PLOS Biology Staff
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Ageing And Cancer As Diseases Of Epigenesis [PDF]
Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome.
Gilbert, Scott F.
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