Results 181 to 190 of about 657,944 (323)

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Quantum computing and the implementation of precision medicine. [PDF]

NPJ Genom Med
Nassir N, Hashmi MA, Raji KG, Jamalalail B, Maksymowsky A, Scherer SW, Alsheikh-Ali A, Uddin M.   +7 more
europepmc   +1 more source

MEMBRANE COMPUTING AS THE PARADIGM FOR MODELING SYSTEMS BIOLOGY [PDF]

, 2013
Ravie Chandren Muniyandi
openalex   +1 more source

A Novel Spatial Search Algorithm for Computing Potentially Transcribed Gene Combinations: A Molecular Biology Network for Behcet's Disease as an Example

, 2023
LI Yu-wei, Junpeng Chen, Zeng Liuting, Yang Kailin, Yehui Peng, Xueyong Liu   +5 more
openalex   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Exploring the computing power of microbes that shapes the environment. [PDF]

Curr Opin Microbiol
Rocha CK, Hueso-Gil Á, Alejaldre L, Rico J, Múgica-Galán P, Goñi-Moreno Á.   +5 more
europepmc   +1 more source

EnvironmentalCensus: Modeling Synthetic Biology EcologicalRisk with Metagenomic Enzymatic Data and High-Performance Computing

John Docter (22772100), Cresten Mansfeldt (16866879)   +1 more
openalex   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

5PSeq Explorer: interactive analysis of co-translational mRNA decay and ribosome dynamics. [PDF]

RNA Biol
Stevens I, Pelechano V.
europepmc   +1 more source

Can exascale computing and explainable artificial intelligence applied to plant biology deliver on the United Nations sustainable development goals? [PDF]

, 2020
Jared Streich, Jonathon Romero, João Gabriel Felipe Machado Gazolla, David Kainer, Ashley Cliff, Érica T. Prates, James B. Brown, Sacha Khoury, Gerald A. Tuskan, Michael R. Garvin, Daniel Jacobson, Antoine Harfouche   +11 more
openalex   +1 more source