Results 221 to 230 of about 657,944 (323)

Metastatic large cell neuroendocrine carcinoma of larynx: Individualizing tumor biology by dual tracer positron emission tomography/computed tomography (⁶⁸Ga-DOTATATE and ¹⁸F-fluorodeoxyglucose) molecular imaging and disease stabilization following ¹⁷⁷Lu-DOTATATE peptide receptor radionuclide therapy after initial progression on chemoradiotherapy

, 2019
Sandip Basu, Sonali Jadhav
openalex   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Insight into Genome-Wide Associations of Growth Trajectories Using a Hierarchical Non-Linear Mixed Model. [PDF]

Biology (Basel)
Zhang Y, Yang L, Cui W, Yang R.
europepmc   +1 more source

Cross-fertilisation at the computing/biology interface: The invention of an algorithmic biology

, 2006
Bullock, Seth
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

ARTreeFormer: A faster attention-based autoregressive model for phylogenetic inference. [PDF]

PLoS Comput Biol
Xie T, Mao Y, Zhang C.
europepmc   +1 more source

Analyzing of Bio computing and Synthetic Biology by using EDAS method

Manjula Selvam, Arunambigai Ramesh, M Ramachandran, Ramya Sharma, Hao Mandeep, Pratyoosh Liu, Shukla, Feifei Cui, Quan Zou, Javier Maca, Francesc Posas, Ricard Sol, Michaela Teravest, Caroline Ajo-Franklin, Jinyoung Seo, Sungi Kim, Ha Park, Jwa-Min Nam, Sierra Brooks, Hal Alper, G Subashini, S Kumar, R Priya, S Jesintha, K Chandrakala, Anamika Singh, Michaela Teravest, Zhongjian Li, Largus Angenent, I Blessy, G Milcah, M Manikandan, Joel, Inaganti Rambabu, Yalavarthy Sreekanth, Le Feuvre, Rosalind, Nigel Scrutton, Raghunadha Reddy, T, M Srilatha, M Sreenivas, N Rajasekhar, M Joel, G Robinson, M Manikandan, Nivetha, Goksel Misirli, A Mahendiran, R Priya, Inaganti Rambabu, Yalavarthy Sreekanth, V Ragavan, N Nithya, Anantharamaiah Vengala, Balambigai Subramanian, C Ambhika, Goksel Misirli, Tramy Nguyen, James Alastair Mclaughlin, Prashant Vaidyanathan, Timothy Jones, Douglas Densmore, Chris Myers, Anil Wipat, Alla Srivani, Gurram Veeraraghavaiah, Nagaraju Dasari, Srinivasa Rao, Bogireddy, Ania-Ariadna Baetica, P Jyothi, G Pradeepini, G Manikandan, G Bhuvaneswari, K Saravanan, M Parameswari, D Sterlin, Rani, P Varma, Prathap Siva, Yamini Adimoolam, Anantharamaiah Lahari Marna, Vengala, Vs Divya, Sundar, Pavan Ram, Kumar, Dr Rani, D Vasudha, K Vasavi, Kumar, Ranjith Kumar, Hemanth Marupudi, Vijayakumar Varadarajan, Krn Kumar, K Kiran, Bhavani, M Sreenivas, T Reddy   +99 more
openalex   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Inferring and summarizing tumor phylogenies from bulk DNA data. [PDF]

Algorithms Mol Biol
Qi Y, Schmidt H, El-Kebir M.
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source