Results 231 to 240 of about 657,944 (323)

Fast phenotype simulation for genotype representation graphs. [PDF]

Bioinform Adv
Syam A, Adonizio C, Wei X.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Publisher Correction: CRISPR-GPT for agentic automation of gene-editing experiments. [PDF]

Nat Biomed Eng
Qu Y, Huang K, Yin M, Zhan K, Liu D, Yin D, Cousins HC, Johnson WA, Wang X, Shah M, Altman RB, Zhou D, Wang M, Cong L.   +13 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Mapping educational needs in bioinformatics in Brazil: adapting ISCB 3.0 competencies to a regional context. [PDF]

Bioinform Adv
Velozo B, Carvalho C, Feitosa R, Leal Pedroza LA, Danzer E, Alves SIA, Neves M, Fam B.   +7 more
europepmc   +1 more source

P43-S Computational Biology Applications Suite for High-Performance Computing (BioHPC.net).

, 2007
J. Pillardy
openalex   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Correction: Global Analysis of Protein and Small-Molecule Substrates of Ubiquitin-Like Proteins. [PDF]

Mol Cell Proteomics
Shao GC, Chen ZL, Lu S, Wu QC, Sheng Y, Wang J, Ma Y, Sui JH, Chi H, Qi XB, He SM, Du LL, Dong MQ.   +12 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Computing the Dissociation Constant from Molecular Dynamics Simulations with Corrections for the Large Pressure Fluctuations-Aquaglyceroporins Have High Affinity for Their Substrate Glycerol. [PDF]

Biomolecules
Mohsin M, Loja HR, Chen LY.
europepmc   +1 more source