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Computational Systems Biology [PDF]

open access: yesThe Scientific World Journal, 2013
The complex biological systems consist of distinct molecules that exert their functions by interacting with each other, which makes it a big challenge to understand how the cellular machinery works. Recently, the accumulation of a large amount of multiscale omics data, such as next-generation sequencing data and protein interaction data, provides ...
Xing-Ming Zhao   +3 more
openaire   +3 more sources

Berkeley Lab Computing Sciences: Accelerating Scientific Discovery [PDF]

open access: yes, 2008
Scientists today rely on advances in computer science, mathematics, and computational science, as well as large-scale computing and networking facilities, to increase our understanding of ourselves, our planet, and our universe.
Hules, John A, Hules, John A.
core   +1 more source

Systems biology in animal sciences [PDF]

open access: yes, 2011
Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Pas, M.F.W., te   +11 more
core   +1 more source

Long non‐coding RNAs and their targets as potential biomarkers in breast cancer

open access: yesIET Systems Biology, 2021
Breast cancer is among the lethal types of cancer with a high mortality rate, globally. Its high prevalence can be controlled through improved analysis and identification of disease‐specific biomarkers.
Maryam Khalid   +9 more
doaj   +1 more source

Long-range order and short-range disorder in Saccharomyces cerevisiae biofilm

open access: yesEngineering Biology, 2019
Biofilm, a colony forming cooperative response of microorganisms under environmental stress, is a major concern for food safety, water safety and drug resistance. Most current works focus on controlling biofilm growth by targeting single genes. Here, the
Vincent Piras   +2 more
doaj   +1 more source

Constraint‐based models for dominating protein interaction networks

open access: yesIET Systems Biology, 2021
The minimum dominating set (MDSet) comprises the smallest number of graph nodes, where other graph nodes are connected with at least one MDSet node. The MDSet has been successfully applied to extract proteins that control protein–protein interaction (PPI)
Adel A. Alofairi   +2 more
doaj   +1 more source

eResearch solutions for high throughput structural biology [PDF]

open access: yes, 2007
Structural biology research places significant demands upon computing and informatics infrastructure. Protein production, crystallization and X-ray data collection require solutions to data management, annotation, target tracking and remote experiment ...
Atkinson, Ian   +11 more
core   +3 more sources

Deep learning approach for microarray cancer data classification

open access: yesCAAI Transactions on Intelligence Technology, 2019
Analysis of microarray data is a highly challenging problem due to the inherent complexity in the nature of the data associated with higher dimensionality, smaller sample size, imbalanced number of classes, noisy data-structure, and higher variance of ...
Hema Shekar Basavegowda, Guesh Dagnew
doaj   +1 more source

The computational stance in biology [PDF]

open access: yesPhilosophical Transactions of the Royal Society B: Biological Sciences, 2019
The goal of this article is to call attention to, and to express caution about, the extensive use of computation as an explanatory concept in contemporary biology. Inspired by Dennett's ‘intentional stance’ in the philosophy of mind, I suggest that a ‘computational stance’ can be a productive approach to evaluating the value of computational concepts ...
openaire   +2 more sources

How Developmental is Evolutionary Developmental Biology? [PDF]

open access: yes, 2002
Evolutionary developmental biology (evo-devo) offers both an account of developmental processes and also new integrative frameworks for analyzing interactions between development and evolution.
Jason Scott Robert, Robert, Jason Scott
core   +1 more source

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