Results 61 to 70 of about 657,944 (323)

Inference and analysis of cell‐cell communication of non‐myeloid circulating cells in late sepsis based on single‐cell RNA‐seq

IET Systems Biology
Sepsis is a severe systemic inflammatory syndrome triggered by infection and is a leading cause of morbidity and mortality in intensive care units (ICUs). Immune dysfunction is a hallmark of sepsis.
Yanyan Tao, Miaomiao Li, Cheng Liu
doaj   +1 more source

Efficient inference of parsimonious phenomenological models of cellular dynamics using S-systems and alternating regression

, 2014
The nonlinearity of dynamics in systems biology makes it hard to infer them from experimental data. Simple linear models are computationally efficient, but cannot incorporate these important nonlinearities.
Daniels, Bryan C., Nemenman, Ilya
core   +2 more sources

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

PMLocMSCAM: Predicting miRNA Subcellular Localisations by miRNA Similarities and Cross‐Attention Mechanism

IET Systems Biology
Many studies have shown that microRNAs (miRNAs) play key roles in some important processes and human complicated diseases. In addition, they also have specific physiological roles at different cellular sites.
Jipu Jiang, Cheng Yan
doaj   +1 more source

Computers from plants we never made. Speculations

, 2017
We discuss possible designs and prototypes of computing systems that could be based on morphological development of roots, interaction of roots, and analog electrical computation with plants, and plant-derived electronic components.
A Adamatzky, A Adamatzky, A Adamatzky, A Trewavas, A Trewavas, AG Volkov, AJ Trewavas, BB Stone, BDL Costello, C Burbach, DB Strukov, E Lehtonen, E Masi, ED Brenner, F Baluška, F Baluška, F Baluška, F Baluška, F Baluška, F Baluška, F Baluška, HH Felle, HP Bais, HP Bais, J Borghetti, J Fromm, JF Miller, K Birbaum, K Yokawa, K Yokawa, L Chua, L Gao, L Geddes, L Kalmar, LO Chua, M Gagliano, M Gagliano, M Gagliano, M Schlicht, MR DeWeese, N Gizzie, P Gács, PW Barlow, R Bellman, S Battistoni, S Mancuso, S Mancuso, S Steinkellner, SP Kosta, TL Graham, V Demin, V Erokhin, WF Dowling, YP Gunji, YV Pershin   +54 more
core   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Computational Biology

International Journal of Advanced Research in Computer Science and Software Engineering, 2018
In the last 20 years, biological sequence data have been accumulating at exponential rate under continuous improvement of sequencing technology, progress in computer science, and steady increase of funding. Molecular sequence databases (e.g., EMBL, Genbank, DDJB, Entrez, Swissprot, etc.) currently collect hundreds of thousands of sequences of ...
Dagmar Klostermeier, Markus G. Rudolph
  +5 more sources

Quantum computing applications in biology

Discover Computing
Recently, there has been significant interest in quantum technology, which utilizes various quantum phenomena, including quantum coherence, entanglement, interference, and superposition, among others.
Morteza Sasani Ghamsari
doaj   +1 more source

Design Environments for Complex Systems [PDF]

, 2003
The paper describes an approach for modeling complex systems by hiding as much formal details as possible from the user, still allowing verification and simulation of the model.
Priami, Corrado
core  

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source