Results 81 to 90 of about 9,602,344 (339)

Computer algebra in systems biology [PDF]

open access: yesarXiv, 2007
Systems biology focuses on the study of entire biological systems rather than on their individual components. With the emergence of high-throughput data generation technologies for molecular biology and the development of advanced mathematical modeling techniques, this field promises to provide important new insights.
arxiv  

Megadomains and superloops form dynamically but are dispensable for X-chromosome inactivation and gene escape

open access: yesNature Communications, 2018
The mammalian inactive X-chromosome (Xi) is organized into megadomains and superloops directed by the noncoding loci, Dxz4 and Firre. Here the authors provide evidence that megadomains do not precede Xist expression or Xi gene silencing, and suggest that
John E. Froberg   +4 more
doaj   +1 more source

Urban fragmentation leads to lower floral diversity, with knock-on impacts on bee biodiversity

open access: yesScientific Reports, 2020
Bees and flowering plants are two closely interacting groups of organisms. Habitat loss and fragmentation associated with urbanisation are major threats to both partners.
Panagiotis Theodorou   +6 more
doaj   +1 more source

Fitzpatrick's Dermatology in General Medicine

open access: yes, 2003
..".surpasses the standards set in all [previous editions]"-Archives of Dermatology, review of prior editionWidely acclaimed dermatological treatise is completely revised and updated with over forty new chapters and an entirely new section on ...
Tobias Pincock
semanticscholar   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale   +9 more
wiley   +1 more source

Loop Quantum Theory Applied to Biology and Nonlinear Whole Biology [PDF]

open access: yesarXiv, 2008
The loop quantum theory, which constitutes a very small discontinuous space, as new method is applied to biology. The model of protein folding and lungs is proposed. In the model, some known results are used, and four approximate conclusions are obtained: their structures are quantized, their space regions are finite, various singularities correspond ...
arxiv  

PROFESSION OF BIOLOGY TEACHER IN UKRAINE: STATISTICAL CHARACTERISTICS

open access: yesНеперервна професійна освіта: теорія та практика
In the context of reforming general secondary education, it is important to identify and analyze the changes occurring in the human resources of the general secondary education system under the influence of various factors, particularly the martial law ...
Lidiia Vashchenko
doaj   +1 more source

PRC1 collaborates with SMCHD1 to fold the X-chromosome and spread Xist RNA between chromosome compartments

open access: yesNature Communications, 2019
The inactive X (Xi)-specific S1/S2 chromosome compartments are merged by SMCHD1, but how the S1/S2 structure is constructed is unclear. The authors find that PRC1 drives the formation of S1/S2s and that the stepwise folding process of the Xi facilitates ...
Chen-Yu Wang   +4 more
doaj   +1 more source

Circulating tumor DNA (ctDNA) trajectories predict survival in trifluridine/tipiracil‐treated metastatic colorectal cancer patients

open access: yesMolecular Oncology, EarlyView.
The authors applied joint/mixed models that predict mortality of trifluridine/tipiracil‐treated metastatic colorectal cancer patients based on circulating tumor DNA (ctDNA) trajectories. Patients at high risk of death could be spared aggressive therapy with the prospect of a higher quality of life in their remaining lifetime, whereas patients with a ...
Matthias Unseld   +7 more
wiley   +1 more source

Imaging Therapeutic PARP Inhibition In Vivo through Bioorthogonally Developed Companion Imaging Agents

open access: yesNeoplasia: An International Journal for Oncology Research, 2012
A number of small-molecule poly (ADP-ribose) polymerase (PARP) inhibitors are currently undergoing advanced clinical trials. Determining the distribution and target inhibitory activity of these drugs in individual subjects, however, has proven ...
Thomas Reiner   +7 more
doaj   +1 more source

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