Results 41 to 50 of about 662,153 (301)

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

Molecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath, Irene A. George, Srikanth S. Manda, Prasanth Ariyannur, Ekta R. Dhawale, Raja Sekhar Kommu, Rajan Datar, Darshana Patil, Vinita Trivedi, Manisha Singh, Kumar Prabhash, Sewanti Limaye, Richa Chauhan, Prashant Kumar   +13 more
wiley   +1 more source

Didactic Models in the Teaching of the ABO System and the Rh Factor: A Review of the Methods and Factors that Influence Learning

Revista Brasileira de Pesquisa em Educação em Ciências
The adoption of didactic models in the teaching of the ABO system and the Rh factor is an alternative for reducing the difficulties encountered by students in the learning process.
Dary Medeiros Dantas, Micheline de Azevedo Lima   +1 more
doaj   +1 more source

EcoCyc: fusing model organism databases with systems biology. [PDF]

, 2012
EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E.
Bonavides-Martínez, César, Collado-Vides, Julio, Fulcher, Carol, Gama-Castro, Socorro, Gunsalus, Robert P, Huerta, Araceli M, Karp, Peter D, Keseler, Ingrid M, Kothari, Anamika, Krummenacker, Markus, Latendresse, Mario, Mackie, Amanda, Muñiz-Rascado, Luis, Ong, Quang, Paley, Suzanne, Paulsen, Ian, Peralta-Gil, Martin, Santos-Zavaleta, Alberto, Schröder, Imke, Shearer, Alexander G, Subhraveti, Pallavi, Travers, Mike, Weerasinghe, Deepika, Weiss, Verena   +23 more
core   +1 more source

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

PENGEMBANGAN BAHAN AJAR BIOLOGI SEL PADA PROGRAM STUDI PENDIDIKAN BIOLOGI UIN ALAUDDIN MAKASSAR

Florea: Jurnal Biologi dan Pembelajarannya, 2014
Learning in UIN Alauddin is still limited knowledge to students, while, one mission to improve the quality of educators Biology in terms of belief, moral and scientific attitudes have not been implemented.
St. Muriati
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Oficinas Pedagógicas na Formação Inicial de Professores de Ciências e Biologia: Espaço para Formação Intercultural

Ciência & Educação
Resumo Este trabalho consiste em analisar as interações do sujeito na posição de futuro professor de ciências e biologia no desenvolvimento de oficinas pedagógicas como espaços de formação intercultural.
Laís de Souza Rédua, Danilo Seithi Kato   +1 more
doaj   +1 more source

Content and Language Integrated Learning Implementation Through Team Teaching in Biology Lessons: A Quasi-Experimental Design With University Students

Frontiers in Education, 2022
Can engaging university students in Content and Language Integrated Learning (CLIL) increase their achievement in Biology and English language? The current study explored the effectiveness of team teaching enhanced CLIL on student achievement.
Malik Satayev, Nuri Balta, Izbassarova R. Shaymerdenovna, Raquel Fernández-Cézar, Gema Alcaraz-Mármol   +4 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Find a Fossil and “Choose your own Adventure”

International Journal of Educational Innovation and Research
Science education university curriculum should foster transformative methods of teaching and learning for science majors, including science communication.
Shem Unger, Mark Rollins
doaj   +1 more source