Results 111 to 120 of about 613,209 (287)

Biomarkers for Huntington's disease: an update [PDF]

, 2012
Huntington's disease (HD) is a devastating autosomal-dominant neurodegenerative condition caused by a CAG repeat expansion in the gene encoding huntingtin which is characterised by progressive motor impairment, cognitive decline and neuropsychiatric ...
Scahill, RI, Tabrizi, SJ, Wild, EJ
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

A novel strategy for detecting multiple mediators in high-dimensional mediation models

Frontiers in Psychiatry
This article presents a novel methodology for detecting multiple biomarkers in high-dimensional mediation models by utilizing a modified Least Absolute Shrinkage and Selection Operator (LASSO) alongside Pathway LASSO.
Pei-Shan Yen, Zhaoliang Zhou, Soumya Sahu, Debarghya Nandi, Olusola Ajilore, Dulal Bhaumik, Dulal Bhaumik   +6 more
doaj   +1 more source

Can Ground-based Telescopes Detect The Oxygen 1.27 Micron Absorption Feature as a Biomarker in Exoplanets ?

, 2012
The oxygen absorption line imprinted in the scattered light from the Earth-like planets has been considered the most promising metabolic biomarker of the exo-life.
Alonso, Anthony, Biller, Delfosse, Edwards, Fujii, Fujii, Gliese, Gray, Gray, Górski, Hajime Kawahara, Hanot, Iwamuro, Jao, Kawahara, Kite, Levine, Lord, Léger, Lépine, Lépine, Michihiro Takami, Motohide Tamura, Mountain, Naoshi Murakami, Olivier Guyon, Pallé, Perryman, Ramsay, Rousselot, Stapelfeldt, Takayuki Kotani, Taro Matsuo, Torres, Traub, Yuka Fujii   +36 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Evaluation of Molecularly Imprinted Polymers for Point-of-Care Testing for Cardiovascular Disease

Sensors, 2019
Molecular imprinting is a rapidly growing area of interest involving the synthesis of artificial recognition elements that enable the separation of analyte from a sample matrix and its determination.
Brian Regan, Fiona Boyle, Richard O’Kennedy, David Collins   +3 more
doaj   +1 more source

Integrating Artificial Intelligence with Real-time Intracranial EEG Monitoring to Automate Interictal Identification of Seizure Onset Zones in Focal Epilepsy

, 2018
An ability to map seizure-generating brain tissue, i.e., the seizure onset zone (SOZ), without recording actual seizures could reduce the duration of invasive EEG monitoring for patients with drug-resistant epilepsy.
Berry, Brent, Brinkmann, Benjamin, Cimbalnik, Jan, Iyer, Ravishankar, Kremen, Vaclav, Stead, Matt, Van Gompel, Jamie, Varatharajah, Yogatheesan, Worrell, Gregory   +8 more
core   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Predicting Disease Severity in Children With Attention Deficit Hyperactivity Disorder Using Dual-Branch Hypothesis Network

IEEE Access
Attention deficit hyperactivity disorder (ADHD) is a prevalent neurodevelopmental disorder in children. Although numerous intelligent methods have been applied for its diagnosis, they seldom address symptom prediction, which is crucial for establishing ...
Ying Chen, Yao Wang, Yibin Tang, Xiaojing Meng   +3 more
doaj   +1 more source