Results 201 to 210 of about 1,859,513 (388)
Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
Cotinine as a Biomarker of Environmental Tobacco Smoke Exposure [PDF]
, 1996 Neal L. Benowitz
openalex +1 more source
Molecular Oncology, EarlyView.This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani +14 more
wiley +1 more source
Molecular Oncology, EarlyView.B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez +17 more
wiley +1 more source
DNA damage in marine mussel Mytilus galloprovincialis as a biomarker of environmental contamination
, 1994 Milica Vukmirovic +4 more
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Biomarker selection in R: the BioMark package [PDF]
, 2012 BioMark is an R package implementing two meta-strategies for finding biomarkers. For two-class discrimination problems, Higher Criticism is available, an approach to define optimal cutoffs for methods like t testing for high-dimensional data. In this work, HC has been extended to multivariate methods, allowing, e.g., selection of biomarkers based on ...
Wehrens, Herman Ronald Maria Johan +1 more
openaire +2 more sources
Molecular Oncology, EarlyView.Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen +12 more
wiley +1 more source
Collection of genomic DNA by buccal swabs for polymerase chain reaction-based biomarker assays. [PDF]
, 1999 A. H. C. Walker +5 more
openalex +1 more source