Results 131 to 140 of about 103,397 (314)

A trans-atlantic perspective on stagnation in clinical translation of antimicrobial strategies for the control of biomaterial-implant associated infection [PDF]

, 2019
Current regulatory requirements impede clinical translation and market introduction of many new antimicrobial combination implants and devices, causing unnecessary patient suffering, doctor frustration, and costs to healthcare payers.
T. Fintan Moriarty, David W. Grainger, Werner Zimmerli, Schmidmaier, Gerhard, Bayston, Roger, Moriarty, T. Fintan, Darouiche, Rabih O., Henny C. van der Mei, Gerhard Schmidmaier, Zimmerli, Werner, Grainger, David W., Fagette, Paul H., Rabih O. Darouiche, Raschke, Michael J., Michael J. Raschke, Baddour, Larry M., Van Der Mei, Henny C., Lynn C. Winterton, Alt, Volker, Thorsten Gehrke, Busscher, Henk J., Javad Parvizi, Zinunerli, Werner, Henk J. Busscher, Gehrke, Thorsten, Roger Bayston, Parvizi, Javad, Volker Alt, van der Mei, Henny C.; id_orcid, Paul H. Fagette, Winterton, Lynn C., Larry M. Baddour   +31 more
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A Long‐Lived Human Neurovascular PENTA Culture Model Captures Incomplete Vascular Repair and Glia‐Associated Signaling After Traumatic Brain Injury

Advanced Healthcare Materials, EarlyView.
A long‐lived, five‐cell‐type human neurovascular (PENTA) model recreates vascular disorganization and incomplete repair after traumatic brain injury (TBI). By integrating endothelial, glial, neuronal, and immune components within a 3D scaffold, the platform enables time‐resolved analysis of neurovascular remodeling and provides a human‐relevant system ...
Daniel S. Hinrichsen, Sunghyun Jun, Colleen M. Arrasmith, Charitha C. Anamala, Mitchell D. Thielen, Anapaula Garcia, Volha Liaudanskaya   +6 more
wiley   +1 more source

Acellularized Biomaterial From Embryonic Stem Cells [PDF]

, 2006
Compositions containing acellularized biomaterial derived from differentiating pluripotent cells, for example, embryonic stem cells are provided. The acellularized biomaterial can be used to promote wound healing, promote tissue regeneration, or inhibit ...

core  

Adverse Reactions to Biomaterials: State of the Art in Biomaterial Risk Assessment, Immunomodulation and In Vitro Models for Biomaterial Testing [PDF]

, 2019
Adverse immune reactions to implants are important bottlenecks for translation of biomaterial discoveries for large scale use. Moreover, recent advances in highthrough-put biomaterial discovery and synthetic biology significantly improves potential risks
Vrana, Nihal Engin, Ghaemmaghami, Amir M., Zorlutuna, Pinar   +2 more
core   +1 more source

Design and Synthesis of Peptide‐Polyester Conjugates for Cell‐Mediated Scaffold Degradation

Advanced Healthcare Materials, EarlyView.
This work describes polycaprolactone (PCL)‐based biomaterials engineered to degrade in response to cell‐secreted proteases. A fast‐degrading peptide (Fast) sequence is integrated into a PCL conjugate backbone to produce a biomaterial that is selectively degraded by multiple cell types compared to its scrambled control (ScrFast).
Korina Vida G. Sinad, Natasha K. Hunt, Srujan Singh, Kelly B. Seims, Yingjie Wu, E. Thomas Pashuck, Warren L. Grayson, Lesley W. Chow   +7 more
wiley   +1 more source

Meta-biomaterials

Biomaterials Science, 2020
This talk examines meta-biomaterials, which are engineered materials that achieve extraordinary physical and biological capabilities through their specific internal structures and surface treatments. By precisely controlling the geometry and topology of these materials at the microscopic level, scientists can dictate how they behave at a larger scale ...
openaire   +5 more sources

Multidimensional Cellular Micro‐Compartments to Model Invasive Lobular Carcinoma Dormancy

Advanced Healthcare Materials, EarlyView.
Invasive lobular carcinoma (ILC) is an understudied subtype of breast cancer that is susceptible to late recurrences. In this study, micro‐compartmentalization techniques spanning multiple dimensions, including 2D, pseudo‐3D, and 3D, are integrated to uncover the mechanisms underlying ILC dormancy, revealing the central role of p27Kip1.
Xilal Y. Rima, Sarmila Majumder, Divya S. Patel, Chunyu Hu, Hong Li, Xin Huang, Kim Truc Nguyen, Jacob Doon‐Ralls, Chiranth K. Nagaraj, Mangesh D. Hade, Setty M. Magaña, Eswar Shankar, Xiaoli Zhang, Daniel G. Stover, Bhuvaneswari Ramaswamy, Eduardo Reátegui   +15 more
wiley   +1 more source

Surface Characterization of Biomaterial Interfaces [PDF]

, 1998
Any biomaterial application involves the creation of at least one interface. For instance, in a vascular graft, interfaces are created between the biomaterial and blood, and between the biomaterial and the walls of the blood vessel.
Fedrizzi, Michele, Anderle, Mariano, Canteri, Roberto, Pederzolli, Cecilia, R. Paradiso   +4 more
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Packed for Ossification: High‐Density Bioprinting of hPDC Spheroids in HAMA Toward Endochondral Ossification

Advanced Healthcare Materials, EarlyView.
Human periosteum‐derived cell spheroids bioprinted at high density within a hyaluronic acid matrix promote fusion and hypertrophic cartilage formation in vitro. Early encapsulation enhances spheroid interaction and matrix maturation, generating scalable cartilage templates intended for endochondral bone regeneration.
Ane Albillos Sanchez, Maria Paula Marks, Paula Casademunt, Adrián Seijas‐Gamardo, Ioannis Papantoniou, Lorenzo Moroni, Carlos Mota   +6 more
wiley   +1 more source

Prosthetic design considerations to optimize peri-implant tissue healing and health – a narrative review

Dentistry Review
The critical prosthetic considerations that influence biological and esthetic outcomes in implant dentistry are often suboptimally translated into clinical practice. Historically, implant placement protocols treated the surgical and restorative phases as
Jason D. Lee, Jessica Poon, Oliver Viera, Kevin Kwon, Richard Liu   +4 more
doaj   +1 more source