Results 161 to 170 of about 156,734 (267)

Kaempferol Attenuates Spaceflight‐Associated Knee Cartilage Degradation by Targeting NOX4‐Mediated Mitochondrial Dysfunction

open access: yesAdvanced Science, EarlyView.
We have shown that both simulated and actual spaceflight contribute to cartilage degradation in the knees of mice. Using RNA sequencing and bioenergetic profiling, we identified NADPH oxidase 4 (NOX4) as a key factor driving these changes. Additionally, we found that kaempferol, a naturally occurring flavonoid that binds directly to NOX4, reduces ...
Yuesong Yin   +23 more
wiley   +1 more source

Spatially Organized Human Ovarian Spheroids Instruct Endometrial Morphogenesis

open access: yesAdvanced Science, EarlyView.
A spatially organized human follicle‐like spheroid (SPHEGaT) composed of granulosa cells (GCs) and stromal‐derived theca‐like cells (TLCs) establishes sustained steroidogenesis in vitro. When co‐cultured with human endometrial organoids (EMOs), estradiol (E2) and progesterone (P4) exchange induces secretory/progesterone‐responsive differentiation ...
Maria João Sousa   +5 more
wiley   +1 more source

Risk of delayed displacement and biomechanical analysis of unstable rib fractures postsurgical. [PDF]

open access: yesWorld J Emerg Surg
Dong G   +10 more
europepmc   +1 more source

Flanking‐Group Engineering Unlocks Emerging Functionalities in Diketopyrrolopyrrole Semiconductors

open access: yesAdvanced Science, EarlyView.
This review presents a comprehensive and unified perspective of flanking‐group engineering in Diketopyrrolopyrrole (DPP) based organic semiconductors that connects molecular‐level design with cross‐device functionalities. By integrating insights from molecular design, solid‐state packing, and device physics, this review seeks to establish general ...
Xiaoyun Wu   +5 more
wiley   +1 more source

Generative tissue modeling for customized biomechanical analysis: a data-driven synthesis framework of simulation-ready 3D shapes. [PDF]

open access: yesFront Bioeng Biotechnol
Ma J   +9 more
europepmc   +1 more source

Systemic Nanomechanical Single‐Cell Profiling Reveals Mechanophenotype Transitions Under Therapeutic Perturbation

open access: yesAdvanced Science, EarlyView.
Single‐cell mechanomics demonstrates that pharmacological perturbation changes cytoskeletal and cortical structure, suppressing cancer cell invasiveness. By integrating atomic force microscopy (AFM)‐based cortical measurements with stimulated emission depletion (STED)‐resolved adhesion and cytoskeletal organization, this approach identifies nanoscale ...
Minhee Ku   +4 more
wiley   +1 more source

Stretchable, Tough, and Luminescent Perovskite Molecular Ferroelectric Composite: Empowering Reliable Self‐Powered Motion Sensing in High Humidity and Subzero Temperatures

open access: yesAdvanced Science, EarlyView.
A flexible molecular ferroelectric composite is fabricated via in situ growth of luminescent DMAA‐MnCl3 ferroelectric crystals within a SEBS/SIS double‐polymer matrix. It delivers 7.54 MPa tensile strength, over 1200% tensile strain, durable piezoelectric motion sensing, and excellent harsh‐environment stability for all‐weather wearable biomechanical ...
Shuangqing Li   +6 more
wiley   +1 more source

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