Results 121 to 130 of about 60,035 (268)

Human centred manufacturing: methodology for ergonomic previsional evaluation of manual assembly operations [PDF]

, 2013
The challenge of flexibility and productivity for manufacturing operations needs a new concept based on “human-centered manufacturing process”. This concept must consider basically the ergonomics of workplaces and workload balancing.
Costantino, Marco, Di Pardo, Massimo, Monferino, Rossella, Spada, Stefania   +3 more
core  

Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis

Advanced Science, EarlyView.
Piezoelectric biomaterials convert mechanical forces into electrical signals, offering novel strategies to restore and modulate bone microenvironments for tissue engineering. This review examines molecular dipole origins, spatial arrangements, and pseudo‐piezoelectric mechanisms and highlights dipole‐engineering techniques for osteogenesis regulation ...
Xiyao Ni, Yufei Cui, Mojtaba Salehi, Mui Ling Sharon Nai, Kun Zhou, Cian Vyas, Boyang Huang, Paulo Bartolo   +7 more
wiley   +1 more source

Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts

Advanced Science, EarlyView.
Mesenchymal stem cell‐derived apoptotic bodies (MSC‐ABs) target keloid fibroblasts (KFs), restoring nicotinamide adenine dinucleotide (NAD) metabolism and mitochondrial function, suppressing collagen overproduction, and rebalancing tissue homeostasis, offering a novel therapy for keloid.
Shutong Qian, Siya Dai, Chunyi Guo, Wenjun Wang, Jiajia Pang, Yichen Shen, Mingyuan Xu, Jie Hu, Wenguo Cui, Xiaoming Sun, Jinghong Xu   +10 more
wiley   +1 more source

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Piezo1 Activation Improves NSCLC Liver Metastasis Immunotherapy by Overriding Matrix Stiffness‐Mediated Bimodal PD‐L1/CXCL10 Regulation

Advanced Science, EarlyView.
This study demonstrates that Piezo1 activation enhances FAK‐YAP‐mediated upregulation of PD‐L1 and CXCL10, thereby promoting an immunotherapy‐responsive tumor microenvironment in NSCLC. Cyclic stretch modulates the PD‐L1/CXCL10 response to ECM stiffness, reshaping their expression dynamics.
Tian Zhang, Yuan Li, Bo Cheng, Zhao Xu, Mengjie Liu, Jinteng Feng, Yixue Bai, Yang Yu, Panpan Jiang, Luying Geng, Feng Xu, Hui Guo   +11 more
wiley   +1 more source

Oscillating Magnetic Field Induced Bone Injury Repair by using Drug‐Free Micromotors

Advanced Science, EarlyView.
This work presents a payload‐free, minimally invasive approach for bone repair using magnetic hydrogel micromotors, which enhance bone regeneration via localized micromovement stimulation, achieving a twofold increase in new bone formation in vivo. Abstract Bone injury repair remains a significant clinical challenge due to the tissue's limited self ...
Jie Shen, Rui He, Jiajun He, Lipeng Liao, Yongcan Huang, Shaoxiong Min, Xiaoreng Feng, Bin Chen, Ben Wang   +8 more
wiley   +1 more source

Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques

Advanced Science, EarlyView.
The study constructs an in vitro Aβ plaque‐associated microglia model and uses SECM and SICM to in situ monitor changes in ROS levels, membrane permeability, and phagocytosis of microglia during Aβ clearance. It is found out that Aβ stiffness triggers microglial activation via the PIEZO1 mechanotransduction pathway, causing neuroinflammation and ...
Yulin Liu, Junjie Zhang, Yuxiang Zhao, Feixiang Fang, Siyu Zhang, Qiqi An, Jian Zhuang, Feng Xu, Fei Li   +8 more
wiley   +1 more source

Multi‐Region Brain Organoids Integrating Cerebral, Mid‐Hindbrain, and Endothelial Systems

Advanced Science, EarlyView.
Multi‐Region Brain Organoids combine cerebral, mid/hindbrain, and endothelial components into an advanced 3D model capturing 80% of fetal brain cellular diversity. This platform reveals essential endothelial‐neural signaling networks that maintain region‐specific intermediate progenitors during hindbrain development.
Anannya Kshirsagar, Hayk Mnatsakanyan, Sai Kulkarni, John Guo, Kai Cheng, Luke Daniel Ofria, Oce Bohra, Ram Sagar, Vasiliki Mahairaki, Christian E Badr, Annie Kathuria   +10 more
wiley   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

Advanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong, Wenxiao Shi, Xingzhu Liu, Hang Yu, Yinghui Wu, Yanzhang Xia, Caichun Yue, Chongkai Yang, Cong Shen, Renjun Pei, Tianwen Xin, Hailong Pei, Jun Shen   +12 more
wiley   +1 more source

Dual‐Modular Hydrogel Microparticles with Precision‐Modulation of Inflammatory Microenvironment Dictate Full‐Thickness Cartilage Regeneration for Osteoarthritis Repair

Advanced Science, EarlyView.
Cartilage injury is a prominent pathological hallmark of osteoarthritis. In this study, we developed a two‐modular hydrogel microparticle system wherein HMP‐A effectively targets the damaged area, while HMP‐B forms an efficient connection with HMP‐A on the cartilage surface.
Xinye Chen, Yuanman Yu, Zirui He, Lina Pan, Jing Wang, Changsheng Liu   +5 more
wiley   +1 more source