Results 131 to 140 of about 60,798 (272)

PIEZO1‐GPX4 Axis Mediates Mechanical Stress‐Induced Vertebral Growth Plate Dysplasia via Ferroptosis Activation

Advanced Science, EarlyView.
Mechanical stress activates PIEZO1 in vertebral growth plate chondrocytes, triggering ferroptosis through direct binding and inhibition of GPX4. This axis promotes lipid peroxidation and pathological ossification, accelerating spinal deformities. Clinical and genetic evidence (Piezo1‐cKO) confirms its role in scoliosis progression.
Fei Chen, Fushuai Peng, Shuqing Chen, Yukun Du, Jianyi Li, Yuanyuan Fan, Zichen Cui, Guanghui Gu, Han Zhang, Zhensong Jiang, Guodong Wang, Xingzhi Jing, Jun Dong, Tao Li, Yongming Xi   +14 more
wiley   +1 more source

Oscillating Magnetic Field Induced Bone Injury Repair by using Drug‐Free Micromotors

Advanced Science, EarlyView.
This work presents a payload‐free, minimally invasive approach for bone repair using magnetic hydrogel micromotors, which enhance bone regeneration via localized micromovement stimulation, achieving a twofold increase in new bone formation in vivo. Abstract Bone injury repair remains a significant clinical challenge due to the tissue's limited self ...
Jie Shen, Rui He, Jiajun He, Lipeng Liao, Yongcan Huang, Shaoxiong Min, Xiaoreng Feng, Bin Chen, Ben Wang   +8 more
wiley   +1 more source

Dual‐Modular Hydrogel Microparticles with Precision‐Modulation of Inflammatory Microenvironment Dictate Full‐Thickness Cartilage Regeneration for Osteoarthritis Repair

Advanced Science, EarlyView.
Cartilage injury is a prominent pathological hallmark of osteoarthritis. In this study, we developed a two‐modular hydrogel microparticle system wherein HMP‐A effectively targets the damaged area, while HMP‐B forms an efficient connection with HMP‐A on the cartilage surface.
Xinye Chen, Yuanman Yu, Zirui He, Lina Pan, Jing Wang, Changsheng Liu   +5 more
wiley   +1 more source

FGF9–FGFR2 Signaling via Osteocytes‐Preosteoblasts Crosstalks to Mediate Mechanotransduction‐Driven Intramembranous Osteogenesis in the Underdeveloped Maxilla

Advanced Science, EarlyView.
This study identifies osteocyte‐derived FGF9 as a mechanosensitive factor that impairs osteogenesis in the underdeveloped maxilla by inducing FGFR2 nuclear translocation in preosteoblasts. Mechanical stimulation reduces FGF9 secretion, relieving its inhibitory effect. These findings reveal a novel osteocyte–preosteoblast FGF9–FGFR2 axis in craniofacial
Yiwen Zhou, Lili Chen, Miaomiao Han, Peixiang Zhu, Yanyi Wang, Xuanxuan Yu, Tingyu Reng, Huijuan Wang, Baochao Li, Caixia Zhang, Ziwei Huang, Shuang Lin, Guoyun Wang, Jie Ge, Baosheng Guo, Huang Li   +15 more
wiley   +1 more source

Lower Limb Kinematics of People With Midfoot Osteoarthritis During Level Walking and Stair Climbing

Journal of Foot and Ankle Research
Background Midfoot osteoarthritis (OA) affects one in eight people over 50, yet its impact on foot and lower limb kinematics remains poorly understood.
Merridy J. Lithgow, Jayishni N. Maharaj, Andrew K. Buldt, Shannon E. Munteanu, Benjamin F. Mentiplay, Hylton B. Menz   +5 more
doaj   +1 more source

Modulating Macrophage–Nucleus Pulposus Cell Crosstalk via Sequential Drug Delivery Attenuates Disc Degeneration

Advanced Science, EarlyView.
The G‐CS/MSN drug delivery system enhances intervertebral disc repair through sequential drug release. Abstract Intervertebral disc degeneration (IDD) is characterized by an inflammatory environment and dysregulation of the extracellular matrix metabolism (ECM).
Xiangzhen Kong, Rui Hu, Peng Zhang, Qi Li, Kangle Song, Hanwen Gu, Jihui Zheng, Shen Liu, Liang Liu, Lin Jin, Lei Cheng, Chengwei Li, Zhijian Wei   +12 more
wiley   +1 more source

Open Challenges and Opportunities in Piezoelectricity for Tissue Regeneration

Advanced Science, EarlyView.
This review provides an intriguing review of the recent advancements, challenges, and future perspectives regarding the application of piezoelectric scaffolds in tissue regeneration. The detailed exposition is anticipated to propel the advancement of personalized and intelligent piezoelectric implants, thereby fostering significant progress in this ...
Xiaoling Deng, Yu Zhuang, Jinjie Cui, Liyun Wang, Huilu Zhan, Xudong Wang, Kaili Lin, Changyong Yuan   +7 more
wiley   +1 more source

Data to accompany "Medial knee cartilage is unlikely to withstand a lifetime of running without positive adaptation: a theoretical biomechanical model of failure phenomena"

, 2020
Ross H. Miller, Rebecca L. Krupenevich
openalex   +2 more sources

Synergy between Defects and Lattice Distortion Drives Self‐Powered Elastico‐Near‐Infrared Mechanoluminescence in Cr3+‐Doped Spinel Oxides

Advanced Science, EarlyView.
This work demonstrates crystal lattice tailoring and defect modulation to engineer a Cr3+‐activated cubic spinel oxide, where strategic introduction of Cr3+ into octahedral Al3+/Li+ sites drives efficient NIR‐ML through a non‐trap‐based mechanism. Abstract Elastico‐mechanoluminescence (ML) enables unique force‐to‐light transduction for applications in ...
Yao Xiao, Kang Chen, Mingzi Sun, Puxian Xiong, Bolong Huang, Yongsheng Sun, Dongdan Chen, Jiulin Gan, Zhongmin Yang   +8 more
wiley   +1 more source

MXene‐Integrated Printed Piezoresistive Flexible Sensors: A Breakthrough in Real‐Time Monitoring for Medical and Smart Applications

Advanced Science, EarlyView.
A chocolate‐inlaid Ag@waffle‐structured MXene is synthesized in this research via template‐directed growth strategy (WSM‐A8). The pressure sensor prepared with the WSM‐A8 presents the highest ΔI/I0 response intensity among the reported MXene‐based piezoresistive sensors with satisfactory sensitivity, outstanding structural stability, and superior ...
Hao‐wen Zhang, Xiang Xu, Di‐wen Jiang, Jie Lu, Yang‐sheng Wang, Zhe‐sheng Feng, Yan Wang   +6 more
wiley   +1 more source