Results 141 to 150 of about 168,694 (291)

Disc mechanical characteristics : construction of a finite element mathematical model, first results [PDF]

, 2014
Computational mechanics is an invaluable tool to analyze biomechanical systems, either in healthy or degenerative conditions, and to improve our understanding on the events that can trigger trauma or diseases, to design new medical devices to restore ...
Alves, J. L., Claro, José Carlos Pimenta   +1 more
core  

Suspended Tissue Open Microfluidic Patterning (STOMP)

Advanced Science, EarlyView.
Suspended Tissue Open Microfluidic Patterning (STOMP) is a method that enables precise spatial patterning within a single suspended tissue. By leveraging capillary pinning and open microfluidics, STOMP facilitates the creation of complex tissue interfaces such as diseased‐healthy boundaries and tissue‐tissue junctions. This method integrates mechanical
Amanda J. Haack, Lauren G. Brown, Alex J. Goldstein, Priti Mulimani, Jean Berthier, Asha R. Viswanathan, Irina Kopyeva, Jamison M. Whitten, Ariel Lin, Serena H. Nguyen, Thomas P. Leahy, Ella E. Bouker, Ruby M. Padgett, Natalie A. Mazzawi, Jodie C. Tokihiro, Ross C. Bretherton, Aaliyah Wu, Stephen J. Tapscott, Cole A. DeForest, Tracy E. Popowics, Erwin Berthier, Nathan J. Sniadecki, Ashleigh B. Theberge   +22 more
wiley   +1 more source

TopoGEN: topology-driven microstructure generation for in silico modeling of fiber network mechanics [PDF]

arXiv
The fields of mechanobiology and biomechanics are expanding our understanding of the complex behavior of soft biological tissues across multiple scales. Given the intricate connection between tissue microstructure and its macroscale mechanical behavior, unraveling this mechanistic relationship remains an ongoing challenge.
arxiv  

Generation of Neural Organoids and Their Application in Disease Modeling and Regenerative Medicine

Advanced Science, EarlyView.
Neural organoids provide a versatile platform for neurological research. Advances in organoid technology have partially achieved human neural tissue complexity in terms of tissue structure, cell diversity, and neural signaling, offering insights into neural disorders and regenerative strategies. Technology advances from biomaterials, bio‐manufacturing,
Ruiqi Huang, Feng Gao, Liqun Yu, Haokun Chen, Rongrong Zhu   +4 more
wiley   +1 more source

Numerical model for material parameter identification of cells [PDF]

, 2017
Bacteria have a complex external layer that render them with an increased stiffness and more resistant to external invasion. The works aims to model the squeezing of a bacteria between two walls, and deduce the composition of bacterial external layer ...
Roldán Blasco, Juan Pedro
core  

Diurnal Release of Airborne Pathogen Spores in Greenhouses via the Synergistic Effects of Relative Humidity and Wind

Advanced Science, EarlyView.
Day‐night cycles trigger sharp relative humidity (RH) shifts in greenhouses. Rapid humidity drops dehydrate Corynespora cassiicola spores, inducing shrinkage, jerking movements, and weakened inter‐spore connections that drive detachment. Wind is essential for dispersal, with even mild airflow enabling rapid pathogen spread. These synergistic effects of
Jiayi Ma, Ali Chai, Yanxia Shi, Xuewen Xie, Lei Li, Sheng Xiang, Xianhua Sun, Tengfei Fan, Baoju Li   +8 more
wiley   +1 more source

Reversal of Stress‐Induced PIEZO1 Elevation with Mechanically Adapted Epicardial Patch for Myocardial Infarction Treatment

Advanced Science, EarlyView.
This work identifies fine‐tuning the expression of PIEZO1 as a critical molecular mechanism underlying the treatment of myocardial infarction by mechanically adapted cardiac patches, which can support the clinical translation of cardiac patch devices.
Yuwen Lu, Sibo Jiang, Ting Shen, Yuan Zhang, Chengbin He, Yun Gao, Liyin Shen, Qiao Jin, Yuting Zhao, Ping Liang, Chaochen Wang, Hongjie Hu, Jin He, Kaicheng Deng, Shuo Wang, Yunhe Chen, Jun Ling, Yang Zhu, Lenan Zhuang   +18 more
wiley   +1 more source

Elasticity‐Driven Nanomechanical Interaction to Improve the Targeting Ability of Lipid Nanoparticles in the Malignant Tumor Microenvironment

Advanced Science, EarlyView.
The elasticity of lipid nanoparticles (LNPs) is essential to their tumor‐targeting efficacy. Softer LNPs penetrate tumors faster and more easily enter into softer cancer cells, while stiffer LNPs show prolonged retention in stiffer tumors. The presence of protumoral M2 macrophages enhances the LNPs uptake into stiffer cancer cells, facilitating ...
Eunhee Lee, Loi Nguyen Dang, Jinsol Choi, Haesoo Kim, Lyndon Bastatas, Soyeun Park   +5 more
wiley   +1 more source

Mechanotransduction Activates Microglia and Impairs Phagocytosis in Stiff Amyloid‐β Plaques

Advanced Science, EarlyView.
The study constructs an in vitro Aβ plaque‐associated microglia model and uses SECM and SICM to in situ monitor changes in ROS levels, membrane permeability, and phagocytosis of microglia during Aβ clearance. It is found out that Aβ stiffness triggers microglial activation via the PIEZO1 mechanotransduction pathway, causing neuroinflammation and ...
Yulin Liu, Junjie Zhang, Yuxiang Zhao, Feixiang Fang, Siyu Zhang, Qiqi An, Jian Zhuang, Feng Xu, Fei Li   +8 more
wiley   +1 more source

Logarithmic Helical Design for Reversed Magnetic Field in Magnetoelastic Soft Matters with Giant Current Outputs

Advanced Science, EarlyView.
According to literatures, magnetoelastic soft materials have achieved a maximum magnetic flux change of 80%, making it difficult to enhance the magnetic flux change. To address this, this manuscript proposed a reversed magnetic field strategy in conjunction with logarithmic helical design and magnetoelastic deformation.
Xiaojun Chen, Farid Manshaii, Dianyu Tang, Yizhuo Xu, Zhuofan Li, Manhui Chen, Peng Chen, Yike Li, Shanfei Zhang, Lei Yang, Jun Chen, Bin Su   +11 more
wiley   +1 more source