Results 301 to 310 of about 521,919 (375)

Lower Extremity Mechanical Energetics During Walking 6 Months Following Anterior Cruciate Ligament Reconstruction. [PDF]

open access: yesScand J Med Sci Sports
Lee H   +10 more
europepmc   +1 more source

Brachyury‐Activated Fucoidan Hydrogel Microspheres Rejuvenate Degenerative Intervertebral Discs Microenvironment

open access: yesAdvanced Science, EarlyView.
This study describes the creation of injectable Brachyury (Bry) mRNA‐loaded Fucoidan‐functionalized GelMA hydrogel microspheres (BLNP@GF). These microspheres efficiently suppress inflammation, enhance extracellular matrix (ECM) synthesis in degenerated nucleus pulposus cells, and mitigate intervertebral disc degeneration (IVDD) in rat models.
Yuhao Gong   +12 more
wiley   +1 more source

Human iPSCs Derived MSCs‐Secreted Exosomes Modulate Senescent Nucleus Pulposus Cells Induced Macrophage Polarization via Metabolic Reprogramming to Mitigate Intervertebral Disc Degeneration

open access: yesAdvanced Science, EarlyView.
Senescent nucleus pulposus cells drive inflammatory M1 macrophage polarization, exacerbating intervertebral disc degeneration (IDD). Conversely, M1 macrophages accelerate NP cell senescence, creating a vicious cycle. iPSCs‐derived mesenchymal stem cell (iMSCs) exosomes break this loop by delivering miR‐100‐5p to suppress mTORC1/glycolysis in ...
Qian Xiang   +10 more
wiley   +1 more source

Short-term effects of Ahmed valve implantation on ocular biometry and corneal biomechanics in neovascular glaucoma. [PDF]

open access: yesBMC Res Notes
Azimi A   +6 more
europepmc   +1 more source

Multiscale Organization of Neural Networks in a 3D Bioprinted Matrix

open access: yesAdvanced Science, EarlyView.
A 3D bioprint model of primary neurons has been engineered with a millimeter‐scale functional neural network, and it recapitulates in vivo transcriptomic features under both normal and disease conditions to the greatest extent. The successful integration of mature neurons and 3D bioprinting signifies a major advance in neuroscience modeling ...
Huiyu Yang   +16 more
wiley   +1 more source

The Search for the Holy Grail in Running Biomechanics: Is There an Ideal Movement Profile for Minimizing Mechanical Overload? [PDF]

open access: yesSports Health
Leporace G   +6 more
europepmc   +1 more source

Dual‐Modular Hydrogel Microparticles with Precision‐Modulation of Inflammatory Microenvironment Dictate Full‐Thickness Cartilage Regeneration for Osteoarthritis Repair

open access: yesAdvanced Science, EarlyView.
Cartilage injury is a prominent pathological hallmark of osteoarthritis. In this study, we developed a two‐modular hydrogel microparticle system wherein HMP‐A effectively targets the damaged area, while HMP‐B forms an efficient connection with HMP‐A on the cartilage surface.
Xinye Chen   +5 more
wiley   +1 more source

Lysosome‐Featured Cell Aggregate‐Released Extracellular Vesicles Regulate Iron Homeostasis and Alleviate Post‐Irradiation Endothelial Ferroptosis for Mandibular Regeneration

open access: yesAdvanced Science, EarlyView.
Lysosomal redistribution occurs via extracellular vesicles in multi‐stem cell aggregates and controls iron homeostasis for safeguarding cell aggregation. These cell aggregate‐released extracellular vesicles (CA‐EVs) rescue lysosomal impairments and exert anti‐ferroptosis effects in recipient irradiated endothelial cells.
Yuan‐Yuan Li   +20 more
wiley   +1 more source

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