Results 51 to 60 of about 515,259 (376)

Biomechanics [PDF]

, 2012
Biomechanics is a vast discipline within the field of Biomedical Engineering. It explores the underlying mechanics of how biological and physiological systems move.
Harris, Gerald F, Slavens, Brooke A.
core   +1 more source

Direct solution of the inverse optimization problem of load sharing between muscles

, 2006
In the context the statically indeterminate muscular load sharing problem considered in biomechanics of the musculoskeletal system, a method is suggested of constructing an additively separable and homogenous cost function based on a solution to a ...
Siemienski, Adam
core   +1 more source

An isovelocity dynamometer method to determine monoarticular and biarticular muscle parameters [PDF]

, 2012
This study aimed to determine whether subject-specific individual muscle models for the ankle plantar flexors could be obtained from single joint isometric and isovelocity maximum torque measurements in combination with a model of plantar flexion ...
Conceição, F, Forrester, SE, King, MA, Lewis, MGC, Yeadon, MR   +4 more
core   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Individualized cyclic mechanical loading improves callus properties during the remodelling phase of fracture healing in mice as assessed from time-lapsed in vivo imaging

Scientific Reports, 2021
Fracture healing is regulated by mechanical loading. Understanding the underlying mechanisms during the different healing phases is required for targeted mechanical intervention therapies.
Esther Wehrle, Graeme R. Paul, Duncan C. Tourolle né Betts, Gisela A. Kuhn, Ralph Müller   +4 more
doaj   +1 more source

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

How to squat? Effects of various stance widths, foot placement angles and level of experience on knee, hip and trunk motion and loading

BMC Sports Science, Medicine and Rehabilitation, 2018
Background Squatting is a core exercise for many purposes. The tissue loading during squatting is crucial for positive adaptation and to avoid injury. This study aimed to evaluate the effect of narrow, hip and wide stance widths, foot position angles (0°,
Silvio Lorenzetti, Mira Ostermann, Fabian Zeidler, Pia Zimmer, Lina Jentsch, Renate List, William R. Taylor, Florian Schellenberg   +7 more
doaj   +1 more source

Evaluation of the strain-line patterns in a human left ventricle: A simulation study [PDF]

, 2015
The aim of this paper is to emphasise the role of the primary strain-line patterns in a human left ventricle (LV) within the complex system that is the heart.
NARDINOCCHI, Paola, S. Gabriele, V. Varano   +2 more
core   +1 more source

Profiling the effect of low frequency mechanical vibration on the metabolic and oxidative stress responses of A431 carcinoma

FEBS Open Bio, EarlyView.
20 Hz mechanical vibration induced A431 cancer cells' apoptosis without such effect on other healthy cell lines of L929 and C2C12. Lowered glucose consumption is observed specifically in A431. The expressions of ROS, HMGB1, and HSP1 levels initially increase and subsequently decrease in the cancer cell line, as opposed to L929 and C2C12, which ...
Wresti L. Anggayasti, Chikahiro Imashiro, Takashi Morikura, Shogo Miyata, Akira Funahashi, Kenjiro Takemura   +5 more
wiley   +1 more source

Application of subject-specific adaptive mechanical loading for bone healing in a mouse tail vertebral defect

Scientific Reports, 2021
Methods to repair bone defects arising from trauma, resection, or disease, continue to be sought after. Cyclic mechanical loading is well established to influence bone (re)modelling activity, in which bone formation and resorption are correlated to micro-
Angad Malhotra, Matthias Walle, Graeme R. Paul, Gisela A. Kuhn, Ralph Müller   +4 more
doaj   +1 more source