Results 61 to 70 of about 1,083,312 (295)

EXACT2: the semantics of biomedical protocols [PDF]

, 2014
© 2014 Soldatova et al.; licensee BioMed Central. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and ...
A Maccagnan, A Pease, A Sackmann, A Sujathaa, Brian B Rudkin, CJ Mungall, Daniel Nadis, Doi, Emma Haddi, Grunwald, H Obokata, I Mura, J Taubert, K Wolstencroft, Larisa N Soldatova, LN Soldatova, LN Soldatova, LN Soldatova, M Courtot, M Hilario, M Schilling, Nigel J Saunders, Piyali S Basu, R Garside, RD King, Ross D King, RR Brinkman, S Mitchell, S Rune, S Shapin, T Bittner, T Klingström, Th Paul, V Rätzel, Véronique Baumlé, W Ceusters, Wolfgang Marwan, Z Xiang   +37 more
core   +3 more sources

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Influence of processing parameters on structural characteristics of porous calcium phosphate samples: a study using an experimental design method

Materials Research, 2005
Synthetic porous ceramics can be used as three-dimensional scaffolds for bone repair. The aim of this work is to correlate process parameters with scaffolds structural characteristics.
José Fernandes de Oliveira Ugarte, Lidia Ágata de Sena, Carlos André de Castro Pérez, Paula Fernandes de Aguiar, Alexandre Malta Rossi, Glória Almeida Soares   +5 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Wireless actuation of bulk acoustic modes in micromechanical resonators [PDF]

, 2016
We report wireless actuation of a Lamb wave micromechanical resonator from a distance of over 1 m with an efficiency of over 15%. Wireless actuation of conventional micromechanical resonators can have broad impact in a number of applications from ...
Brown, Benjamin, Erramilli, Shyamsunder, Mateen, Farrukh, Mohanty, Pritiraj   +3 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The Impact of Optogenetics on Regenerative Medicine

Applied Sciences, 2019
Optogenetics is a novel strategic field that combines light (opto-) and genetics (genetic) into applications able to control the activity of excitable cells and neuronal circuits.
Gianrico Spagnuolo, Fabio Genovese, Leonzio Fortunato, Michele Simeone, Carlo Rengo, Marco Tatullo   +5 more
doaj   +1 more source

Concepts and characteristics of the 'COST Reference Microplasma Jet' [PDF]

, 2016
Biomedical applications of non-equilibrium atmospheric pressure plasmas have attracted intense interest in the past few years. Many plasma sources of diverse design have been proposed for these applications, but the relationship between source ...
, A Sobota, B Redeker, Bahre H, Becker K, Beijer P A C, D O’Connell, Ehlbeck J, G Kroesen, Hemke T, J Golda, J Held, Kawamura E, Kelly S, Kelly S, Kelly S, Knake N, Kong M, Lazzaroni C, Lazzaroni C, M Konkowski, M M Turner, Maletić D, Marinov D, N St J Braithwaite, Niemi K, Niermann B, P Beijer, S Reuter, Schneider S, Schulz-von der Gathen V, T Gans, V Schulz-von der Gathen, Vorac J, Wagenaars E, Winter J   +35 more
core   +4 more sources