Results 111 to 120 of about 3,385,345 (371)

Single‐cell transcriptomics redefines focal neuroendocrine differentiation as a distinct prostate cancer pathology

Molecular Oncology, EarlyView.
Single‐cell transcriptomics of prostate cancer patient‐derived xenografts reveals distinct features of neuroendocrine (NE) subtypes. Tumours with focal NE differentiation (NED) share transcriptional programmes with adenocarcinoma, differing from large and small cell neuroendocrine prostate cancer (NEPC). Our work defines the molecular landscape of NEPC,
Rosalia Quezada Urban, Shivakumar Keerthikumar, Ashlee Clark, Hong Wang, Belinda Phipson, Andrew Bakshi, Andrew Ryan, Heather Thorne, Renea A. Taylor, Mitchell G. Lawrence, Gail P. Risbridger, Roxanne Toivanen, David L. Goode   +12 more
wiley   +1 more source

Microglia limit brain tumor development by restricting tumor cell proliferation and inducing T‐cell immunity

Molecular Oncology, EarlyView.
Microglia (BV2) and IL‐4‐treated BMDMs promote astrocytoma clustering and inhibit tumor growth, not shown in other macrophage cells. In vivo, microglial co‐implantation enhances CD8+ T cell infiltration, elevates Granzyme B, lowers circulating MDSCs, and extends survival only in immune‐competent mice, but not in immune‐deficient mice.
Tzu‐Chieh Sun, Ching‐Fang Yu, Sheng‐Yan Wu, Wei‐Chung Cheng, Chi‐Shiun Chiang, Fang‐Hsin Chen   +5 more
wiley   +1 more source

Static structural analysis of different stem designs used in total hip arthroplasty using finite element method

Heliyon, 2019
Background: The Hip joint is the primary joint which gives stability to the human body. The wear and tear associated with age and other factors, require these joints to be replaced by implants using hip arthroplasty surgeries. Cobalt chromium alloy (CoCr)
Chethan K.N., Mohammad Zuber, Shyamasunder Bhat N., Satish Shenoy B., Chandrakant R. Kini   +4 more
doaj  

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Advances in the scaffolds fabrication techniques using biocompatible polymers and their biomedical application: A technical and statistical review

Journal of Saudi Chemical Society, 2020
With the advancement in tissue engineering, researchers are working hard on new techniques to fabricate more advanced scaffolds from biocompatible polymers with enhanced porosity, appropriate mechanical strength, diverse shapes and sizes for potential ...
Adnan Haider, Sajjad Haider, Madhusudana Rao Kummara, Tahseen Kamal, Abdul-Aziz A Alghyamah, Faiza Jan Iftikhar, Bushra Bano, Naeem Khan, Mohammad Amjid Afridi, Sung Soo Han, Ali Alrahlah, Rawaiz Khan   +11 more
doaj  

How to Learn Multidisciplinary Design: Biomedical Engineering in Cross Cultural Seminar [PDF]

Journal of Systemics, Cybernetics and Informatics, 2016
The way to learn multidisciplinary design has been discussed. "Biomedical engineering" is exemplified for multidisciplinary field. "Biomedical Engineering" makes the multidisciplinary research area, which includes biology, medicine, engineering, and ...
Shigehiro Hashimoto
doaj  

Antibacterial Pathways in Transition Metal-Based Nanocomposites: A Mechanistic Overview

International Journal of Nanomedicine, 2022
Chinmaya Mutalik,1,2 I-Hsin Lin,3 Dyah Ika Krisnawati,4 Siti Khaerunnisa,5 Muhamad Khafid,6 Widodo,7 Yu-Cheng Hsiao,1,8– 10 Tsung-Rong Kuo1,2 1International Ph.D.
Mutalik C, Lin IH, Krisnawati DI, Khaerunnisa S, Khafid M, Widodo, Hsiao YC, Kuo TR   +7 more
doaj  

Co‐overexpression of the caloric restriction‐induced mitochondrial factors PGC‐1α and MIPEP upregulates Phospho1 expression in adipocytes

FEBS Open Bio, EarlyView.
Caloric restriction that extends lifespan induces the expression of PGC‐1α and MIPEP in white adipose tissue. In this study, co‐overexpression of Pgc‐1α and Mipep upregulated the gene expression of PHOSPHO1. These findings provide new insights into mitochondria‐related mechanisms underlying the effects of caloric restriction in adipocytes.
Mamiko Ishimatsu, Kanari Taki, Asuka Hayami, Komachi Kato, Yuka Nozaki, Yuhei Mizunoe, Takumi Narita, Ryoichi Mori, Yoshikazu Higami, Masaki Kobayashi   +9 more
wiley   +1 more source

A Novel Two-Stage 3D-Printed Halbach Array-Based Device for Magneto-Mechanical Applications

Magnetochemistry
This research unveils a versatile Halbach array magnetic device with promising biomedical applications, offering innovative solutions for targeted therapy and disease management in evolving biomedical engineering.
Antonios Makridis, Nikolaos Maniotis, Dimitrios Papadopoulos, Pavlos Kyriazopoulos, Makis Angelakeris   +4 more
doaj   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source