Results 81 to 90 of about 1,016,426 (283)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

CDIO Experiences in Biomedical Engineering: Preparing Spanish Students for the Future of Medicine and Medical Device Technology [PDF]

, 2016
Biomedical engineering is one of the more recent fields of engineering, aimed at the application of engineering principles, methods and design concepts to medicine and biology for healthcare purposes, mainly as a support for preventive, diagnostic or ...
Carpio Huertas, Jaime, Claramunt Alonso, Rafael, Díaz Lantada, Andrés, Jiménez Fernández, Javier, Muñoz García, Julio, Ros Felip, Antonio, Serrano Olmedo, José Javier   +6 more
core  

Treatment of chronic heart failure in the 21st century: A new era of biomedical engineering has come

Chronic Diseases and Translational Medicine, 2019
Chronic heart failure (CHF) is a challenging burden on public health. Therapeutic strategies for CHF have developed rapidly in the past decades from conventional medical therapy, which mainly includes administration of angiotensin-converting enzyme ...
Chun-Song Hu, Qing-Hua Wu, Da-Yi Hu, Tengiz Tkebuchava   +3 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Sputtering of Electrospun Polymer-Based Nanofibers for Biomedical Applications: A Perspective

Nanomaterials, 2019
Electrospinning has gained wide attention recently in biomedical applications. Electrospun biocompatible scaffolds are well-known for biomedical applications such as drug delivery, wound dressing, and tissue engineering applications.
Hana Kadavil, Moustafa Zagho, Ahmed Elzatahry, Talal Altahtamouni   +3 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

How to Learn Multidisciplinary Design: Biomedical Engineering in Cross Cultural Seminar [PDF]

Journal of Systemics, Cybernetics and Informatics, 2016
The way to learn multidisciplinary design has been discussed. "Biomedical engineering" is exemplified for multidisciplinary field. "Biomedical Engineering" makes the multidisciplinary research area, which includes biology, medicine, engineering, and ...
Shigehiro Hashimoto
doaj  

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

A Novel Two-Stage 3D-Printed Halbach Array-Based Device for Magneto-Mechanical Applications

Magnetochemistry
This research unveils a versatile Halbach array magnetic device with promising biomedical applications, offering innovative solutions for targeted therapy and disease management in evolving biomedical engineering.
Antonios Makridis, Nikolaos Maniotis, Dimitrios Papadopoulos, Pavlos Kyriazopoulos, Makis Angelakeris   +4 more
doaj   +1 more source

Microfluidic electro‐viscoelastic manipulation of extracellular vesicles

FEBS Open Bio, EarlyView.
The electro‐viscoelastic manipulation as a potential method for separation of particles based on size. The particles introduced as a sheath flow migrate to the channel center under the influence of simultaneously applied electric field and pressure driven flow.
Seyedamirhosein Abdorahimzadeh, Éva Bozó, Zikrullah Bölükkaya, Artem Zhyvolozhnyi, Anatoliy Samoylenko, Henrikki Liimatainen, Seppo J. Vainio, Caglar Elbuken   +7 more
wiley   +1 more source