Results 41 to 50 of about 370,064 (293)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Imaging of fluorescent polymer dots in relation to channels and immune cells in the lymphatic system

open access: yesMaterials Today Bio, 2022
Polymer dots (Pdots) have been applied to imaging lymph nodes (LNs) and lymphatic vessels (LVs) in living mice and rats. However, the mechanism of absorption, distribution, metabolism, and excretion of Pdots in LNs and LVs is still unclear.
Yufan Zhang   +8 more
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

open access: yesMolecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié   +13 more
wiley   +1 more source

Towards Multimodal Equipment to Help in the Diagnosis of COVID-19 Using Machine Learning Algorithms

open access: yesSensors, 2022
COVID-19 occurs due to infection through respiratory droplets containing the SARS-CoV-2 virus, which are released when someone sneezes, coughs, or talks. The gold-standard exam to detect the virus is Real-Time Polymerase Chain Reaction (RT-PCR); however,
Ana Cecilia Villa-Parra   +14 more
doaj   +1 more source

Development of Nano-economy as a Factor of Forming the Effective National Innovation System of Singapore [PDF]

open access: yes, 2016
The article reveals the theoretical and methodological interpretation of the innovation system, when it determined the structure of the national innovation system. It is noted that the components of the national innovation system are elements, stages and
Ostapenko, T. (Tetiana)
core   +2 more sources

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

open access: yesMolecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg   +43 more
wiley   +1 more source

Augmented reality-based feedback for technician-in-the-loop C-arm repositioning

open access: yesHealthcare Technology Letters, 2018
Interventional C-arm imaging is crucial to percutaneous orthopedic procedures as it enables the surgeon to monitor the progress of surgery on the anatomy level.
Mathias Unberath   +8 more
doaj   +1 more source

Skylab experiments. Volume 6: Mechanics [PDF]

open access: yes, 1973
Skylab program activities are presented in a form adapted to instruction of high school students. The overall goals of the program are discussed. The specific accomplishments of the mechanics investigations are described.

core   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

open access: yesMolecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Assessment of the operational status of medical equipment in public hospitals in the Amhara region, Ethiopia: a sub-national study

open access: yesDiscover Health Systems
Background The functionality of medical equipment is critical for effective clinical service delivery. Despite the growing use of advanced medical equipment, the majority of hospitals in the Amhara region face difficulties, such as inadequate maintenance
Negese Sewagegn   +3 more
doaj   +1 more source

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