Results 31 to 40 of about 2,765,310 (254)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Calibration‐free structured‐light‐based 3D scanning system in laparoscope for robotic surgery

Healthcare Technology Letters
Accurate 3D shape measurement is crucial for surgical support and alignment in robotic surgery systems. Stereo cameras in laparoscopes offer a potential solution; however, their accuracy in stereo image matching diminishes when the target image has few ...
Ryo Furukawa, Elvis Chen, Ryusuke Sagawa, Shiro Oka, Hiroshi Kawasaki   +4 more
doaj   +1 more source

Clinical comparison of sub-mm high-resolution non-contrast coronary CMR angiography against coronary CT angiography in patients with low-intermediate risk of coronary artery disease: a single center trial

Journal of Cardiovascular Magnetic Resonance, 2021
Background The widespread clinical application of coronary cardiovascular magnetic resonance (CMR) angiography (CMRA) for the assessment of coronary artery disease (CAD) remains limited due to low scan efficiency leading to prolonged and unpredictable ...
Reza Hajhosseiny, Imran Rashid, Aurélien Bustin, Camila Munoz, Gastao Cruz, Muhummad Sohaib Nazir, Karine Grigoryan, Tevfik F. Ismail, Rebecca Preston, Radhouene Neji, Karl Kunze, Reza Razavi, Amedeo Chiribiri, Pier Giorgio Masci, Ronak Rajani, Claudia Prieto, René M. Botnar   +16 more
doaj   +1 more source

Polarizer-Free AOTF-Based SWIR Hyperspectral Imaging for Biomedical Applications

, 2020
Optical biomedical imaging in short wave infrared (SWIR) range within 0.9–1.7 μm is a rapidly developing technique. For this reason, there is an increasing interest in cost-effective and robust hardware for hyperspectral imaging data acquisition
Alexander Vinogradov, Sergey Boritko, Grigoriy Martynov, Vitold Pozhar, Alexander Machikhin, Vladimir Lomonov, Vladislav Batshev, Milana Sharikova   +7 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Computer Methods in Biomechanics and Biomedical Engineering: Imaging & Visualization

, 2013
Subject Classifications Applied Mathematics; Biomaterials; Biomaterials; Biomaterials & Medical Devices; Biomechanics; Biomechanics and Human Movement Science; Biomedical Engineering; Engineering & Technology; Fluid Mechanics; Materials Science ...
SGALLARI, FIORELLA
core   +1 more source

The effects of segmentation algorithms on the measurement of 18F-FDG PET texture parameters in non-small cell lung cancer

EJNMMI Research, 2017
Background Measures of tumour heterogeneity derived from 18-fluoro-2-deoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scans are increasingly reported as potential biomarkers of non-small cell lung cancer (NSCLC) for ...
Usman Bashir, Gurdip Azad, Muhammad Musib Siddique, Saana Dhillon, Nikheel Patel, Paul Bassett, David Landau, Vicky Goh, Gary Cook   +8 more
doaj   +1 more source

A general 11C-labeling approach enabled by fluoride-mediated desilylation of organosilanes

Nature Communications, 2020
Convenient and fast methods to introduce 11C into organic molecules are of great help for molecular imaging studies. Here, the authors developed an efficient incorporation of [11C]CO2 and [11C]CH3I into molecules via a fluoride-mediated desilylation ...
Wenchao Qu, Bao Hu, John W. Babich, Nicole Waterhouse, Marybeth Dooley, Shashikanth Ponnala, Julie Urgiles   +6 more
doaj   +1 more source