Results 81 to 90 of about 677,625 (300)
Digital twins to accelerate target identification and drug development for immune‐mediated disorders
FEBS Open Bio, EarlyView.Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley +1 more source
IEEE AccessClinical diagnoses of mental health disorders are often subjective, leading to misdiagnoses and underdiagnoses. AI-based diagnostic tools have emerged as promising approaches for improving diagnostic accuracy. However, effective models with interpretable
Segun Olatinwo, Rita Orji
doaj +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
User's manual for SESL-EMU biomedical monitoring and computations system Final report [PDF]
Biomedical monitoring and computation ...
core +1 more source
Biomedical Sensors Based Monitoring System
, 2018 Electricity-operated durable medical equipment (DME), such as ventilators, dialysis machines, and patient monitoring devices, are life-supporting machines used extensively by patients at home. While convenient and economical, at-home use of DME is susceptible to power outages, especially the ones caused by natural disasters that often occur in large ...
openaire +1 more source
Lessons Learned From a Delayed‐Start Trial of Modafinil for Freezing of Gait in Parkinson's Disease
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Freezing of gait (FOG) in people with Parkinson's disease (PwPD) is debilitating and has limited treatments. Modafinil modulates beta/gamma band activity in the pedunculopontine nucleus (PPN), like PPN deep brain stimulation. We therefore tested the hypothesis that Modafinil would improve FOG in PwPD.
Tuhin Virmani +8 more
wiley +1 more source
Learning from medical data streams: an introduction [PDF]
, 2011 Clinical practice and research are facing a new challenge created by the rapid growth of health information science and technology, and the complexity and volume of biomedical data.
Gaber, M. +3 more
core +1 more source
Respiration monitoring by combining EMG and bioimpedance measurements
, 2018 Full abstract in the ...
Kusche, Roman, Ryschka, Martin
core +1 more source
Applying an Ethical Lens to the Treatment of People With Multiple Sclerosis
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT The practice of neurology requires an understanding of clinical ethics for decision‐making. In multiple sclerosis (MS) care, there are a wide range of ethical considerations that may arise. These involve shared decision‐making around selection of a disease‐modifying therapy (DMT), risks and benefits of well‐studied medications in comparison to
Methma Udawatta, Farrah J. Mateen
wiley +1 more source
Reengineering Biomedical Engineering Curricula: A New Product Development Approach [PDF]
, 2002 Product development engineers in medical industries have created design control procedures to ensure high quality designs that are as error-free as possible.
Ropella, Kristina M. +2 more
core +1 more source