Results 131 to 140 of about 2,344,465 (331)

Electrical pulse stimulation reflecting the episodic nature of real‐life exercise modulates metabolic and secretory profile of primary human myotubes

open access: yesFEBS Open Bio, EarlyView.
Here, we introduced an intermittent electrical stimulation protocol mimicking the episodic nature of real‐life exercise in vitro by alternating low‐ and high‐frequency stimulation. In comparison with widely used continuous stimulation, it enhanced the rate of glucose and fatty acid oxidation, but not the myokine release.
Klára Gabrišová   +11 more
wiley   +1 more source

АССОЦИАЦИЯ АЛЛЕЛЬНЫХ ВАРИАНТОВ КОМБИНИРОВАННОГО ГЕНЕТИЧЕСКОГО РИСКА ДЕФИЦИТА ВИТАМИНА D С ТЯЖЕЛЫМ ИДИОПАТИЧЕСКИМ СКОЛИОЗОМ У РОССИЙСКИХ ПАЦИЕНТОВ

open access: yesРоссийские биомедицинские исследования
Введение. Идиопатический сколиоз (ИС) — распространенное заболевание позвоночника, которое встречается у 2–4% людей во всем мире. Имеется большой массив исследований по определению связи между концентрацией витамина D в крови и ИС.
Константин Григорьевич Буслов   +9 more
doaj   +1 more source

Biomedical researchers’ perspectives on the reproducibility of research

open access: yesPLOS Biology
We conducted an international cross-sectional survey of biomedical researchers’ perspectives on the reproducibility of research. This study builds on a widely cited 2016 survey on reproducibility and provides a biomedical-specific and contemporary perspective on reproducibility.
Kelly D. Cobey   +6 more
openaire   +3 more sources

Structural and functional analysis of Bacillus sarcosine oxidase and its activity toward cyclic imino acids

open access: yesFEBS Open Bio, EarlyView.
Sarcosine oxidase from Bacillus sp. (SoxB) recognizes l‐proline (l‐Pro), d‐proline (d‐Pro), and l‐thioproline (l‐Tpr) as minor substrates. In this study, we measured their absorption spectra, determined the crystal structures of their enzyme complexes, and performed site‐directed mutagenesis of key residues.
Yuqi Zhang   +5 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

open access: yesFEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini   +2 more
wiley   +1 more source

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